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TranscriptomicsPhenotype Enhancement Screen of a Regulatory spx Mutant Unveils a Role for the ytpQ Gene in the Control of Iron Homeostasis.
Spx is a global regulator of genes that are induced by disulfide stress in Bacillus subtilis. Most of the Spx-regulated genes (SRGs) are of unknown function, but many encode products conserved in low %GC Gram positive bacteria. Using a gene-disruption library of B. subtilis genomic mutations, the SR...
ORGANISM(S): Bacillus subtilis 
2011-10-24 | E-GEOD-28872 | biostudies-arrayexpress
TranscriptomicsResponse of Methicillin-resistant Staphylococcus aureus to Amicoumacin A
Methicillin resistant Staphylococcus aureus (MRSA) infection is becoming refractory to existing antibiotic therapy owing to the inherent ability of S. aureus to develop rapid resistance and is considered a major threat to public health. We found that a natural isolate of Bacillus pumilus from the C...
ORGANISM(S): Staphylococcus aureus 
2012-07-30 | E-GEOD-31342 | biostudies-arrayexpress
TranscriptomicsExpression data in wild type and NsrR-null mutant of B. subtilis
NsrR strongly represses transcription of small numbers of genes in the absence of NO NsrR moderately represses transcription of large numbers of genes in a less NO-sensitive manner The wild-type and mutant cells were cultured anaerobically in the presence and absence of NO. Biological triplicate sa...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2011-10-27 | E-GEOD-33289 | biostudies-arrayexpress
TranscriptomicsA new Rrf2 repressor family member, SaiR, controls transcription of spxA2 encoding a regulator of the oxidative stress response in Bacillus anthracis.
Spx, a member of the ArsC (arsenate reductase) protein family, is highly conserved in Gram-positive bacteria, where it interacts with RNA polymerase to activate transcription in response to toxic oxidants.  In Bacillus anthracis, resistance to oxidative stress requires the activity of two paralogou...
ORGANISM(S): Bacillus anthracis 
2014-05-21 | E-GEOD-57851 | biostudies-arrayexpress
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