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TranscriptomicsThe Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-49968 | biostudies-arrayexpress
TranscriptomicsND and HFD memory phenotype CD4 T cells
We used microarray analysis to identify specific molecular mechanisms controlling Th17 cell differentiation in HFD mice Memory phenotype CD4 T cells derived from ND or HFD mice were selected for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2015-07-02 | E-GEOD-70472 | biostudies-arrayexpress
TranscriptomicsThe polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells.
Following antigen encounter by CD4 T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2 was found to specifically enhance T-helper (Th)1 and Th2 cell differentiation and plasticity. Ezh2 directly bo...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-50729 | biostudies-arrayexpress
GenomicsThe polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells [ChIP-seq]
Following antigen encounter by CD4 T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2 was found to specifically enhance T-helper (Th)1 and Th2 cell differentiation and plasticity. Ezh2 directly bo...
ORGANISM(S): Mus musculus 
2013-09-24 | E-GEOD-51079 | biostudies-arrayexpress
TranscriptomicsIdentification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFbeta [Affymetrix]
IL-4 plays an important role in the induction of Th2 and Th9 cells as well as in the inhibition of Th1 cell generation. We herein show that a combination of IL-4 and TGFbeta augment the development of Th1 cells that express CD103 (CD103+ Th1 cells) if IFNgamma is present. The T-box containing tran...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36520 | biostudies-arrayexpress
TranscriptomicsIdentification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFbeta [Agilent]
IL-4 plays an important role in the induction of Th2 and Th9 cells as well as in the inhibition of Th1 cell generation. We herein show that a combination of IL-4 and TGFbeta augment the development of Th1 cells that express CD103 (CD103+ Th1 cells) if IFNgamma is present. The T-box containing tran...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36554 | biostudies-arrayexpress
TranscriptomicsSpatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes
Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together mediate transcriptional counterregulation remains unknown. Genome-wide analysis revealed that binding of Ezh2 and Menin, central members of the PcG and Tr...
ORGANISM(S): Mus musculus 
2015-09-08 | E-GEOD-72757 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity
Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear. GATA3, a master regulator of Th2 cell differentiation...
ORGANISM(S): Mus musculus 
2013-04-19 | E-GEOD-46185 | biostudies-arrayexpress
TranscriptomicsA novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus
IL-5 is a key cytokine that plays an important role in the development of pathological conditions in chronic allergic inflammation. Identification of a strategy to inhibit IL-5 production is important for establishment of new therapies for allergic inflammation. We found that SH-2251, a novel thio...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-42131 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wounds from ovariectomized MIF null mice and controls to investigate the role of MIF during wound healing using BALB/C MIF null mice
The aim of this experiment was to investigate the role of MIF during wound healing using BALB/C MIF null mice and in the context of reduced estrogen-associated impaired healing using ovariectomized mice (a mouse model of age-associated delayed healing). Ageing is associated with delayed cutaneous wo...
ORGANISM(S): Mus musculus 
2005-11-05 | E-MEXP-209 | biostudies-arrayexpress
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