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TranscriptomicsSTATs Shape the Active Enhancer Landscape of T Cell Populations
Signaling pathways are intimately involved in cellular differentiation, allowing cells to respond to their environment by regulating gene expression. While enhancers are recognized as key elements that regulate selective gene expression, the interplay between signaling pathways and actively used enh...
ORGANISM(S): Mus musculus 
2012-11-24 | E-GEOD-40463 | biostudies-arrayexpress
GenomicsType I Interferon induces binding of STAT1 to Bcl6: Divergent Roles of STAT-family transcription factors in the T follicular helper cell genetic program
CD4+ T follicular helper cells (TFH) are critical for the formation and function of B cell responses to infection or immunization, but also play an important role in autoimmunity. The factors that contribute to the differentiation of this helper cell subset are incompletely understood, although seve...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-51531 | biostudies-arrayexpress
GenomicsEarly T-helper 1 Differentiation Is Marked by A Follicular Helper-like Transition: Differential Roles of STAT4 and T-bet
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we show IL-12 acting via signal transducer and activator of transcription 4 (STAT4) induced both Il21 and Bcl6 genes, generating ...
ORGANISM(S): Mus musculus 
2011-12-27 | E-GEOD-33802 | biostudies-arrayexpress
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