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TranscriptomicsThe transcriptional response of Pasteurella multocida to three classes of antibiotics
We studied the effects of three classes of antibiotics (amoxicillin, chlortetracycline and enrofloxacin ) on P. multocida transcriptome using custom oligonucleotide microarrays from Nimblegen systems. All the 2015 genes of Pm70 were spotted on the array and hybridizations were carried out with RNA i...
ORGANISM(S): Pasteurella multocida subsp. multocida str. Pm70 
2009-09-01 | E-GEOD-12779 | biostudies-arrayexpress
ProteomicsHost response to S. pneumoniae TIGR4 and ΔpotABCD
The aim of this experiment is to determine the difference in protein expression, if any, in a mouse model of pneumococcal pneumonia using wild type and a polyamine transport operon deletion mutant strain of S. pneumoniae TIGR4, using expression proteomics. Eight week old female C57bl/6 mice were use...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-27 | PXD002300 | Pride
Lung Mouse Streptococcal pneumonia 
TranscriptomicsPorcine gene response following incision with energized devices
This study compares the gene expression changes in Sus scrofa in response to two different methods for abdominal surgical incisions ; electrosurgery and harmonic blade. As the use of laparoscopic surgery has become more widespread in recent years, the need has increased for minimally-invasive surgic...
ORGANISM(S): Sus scrofa 
2013-12-15 | E-GEOD-47710 | biostudies-arrayexpress
ProteomicsThe role of cadaverine synthesis on pneumococcal capsule and protein expression.
S. pneumoniae TIGR4 wild type strain and lysine decarboxylase deficient strain were cultured in quadruplicate in THY. Proteins were isolated, quantified, trypsin digested and analyzed by 1D LC ESI MS/MS.
ORGANISM(S): Streptococcus pneumoniae TIGR4 
2018-01-24 | PXD008621 | Pride
Metabolism Complementation Cadaverine. Proteomics Polyamines Capsule Pneumococcal pneumonia Streptococcus pneumoniae 
TranscriptomicsRNA-seq analysis of transport deficient S. pneumoniae TIGR4 mutants
The polyamine transport operon in Streptococcus pneumoniae TIGR4 is necessary for survival in murine models of pneumococcal pneumonia. To date, there is no description of polyamine transport dependent pneumococcal gene expression. In this study, we compared gene expression between the wild-type and ...
ORGANISM(S): Streptococcus pneumoniae 
2017-08-14 | E-MTAB-5951 | biostudies-arrayexpress
TranscriptomicsImpact of impaired polyamine biosynthesis on Streptococcus pneumoniae TIGR4 gene expression
The polyamine biosynthesis gene, speE, in Streptococcus pneumoniae TIGR4 is necessary for survival in murine models of pneumococcal pneumonia. To date, there is no description of polyamine biosynthesis dependent pneumococcal gene expression. In this study, we compared gene expression between the wil...
ORGANISM(S): Streptococcus pneumoniae 
2023-01-01 | E-MTAB-6070 | biostudies-arrayexpress
TranscriptomicsHigh density Tiling array analysis of Streptococcus pneumoniae TIGR4 genome
The objective of the study is to obtain a high resolution transcription map of S. pneumoniae genome and make it available through a genome browser. The study also help to identify gene expression pattern, presence of small RNAs, Antisense expression and operon structure. S. pneumoniae strain TIGR4 (...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-06 | E-GEOD-12636 | biostudies-arrayexpress
TranscriptomicsRNA-Seq based transcriptional map of bovine respiratory disease pathogen 'Histophilus somni 2336'
We used RNA-Seq to experimentally annotate H. somni strain 2336 and construct a single nucleotide resolution transcriptome map. Novel expressed elements were identified, and where appropriate, computational predictions of previously described gene boundaries were corrected. Transcript profiling of a...
ORGANISM(S): Histophilus somni 
2011-09-30 | E-GEOD-29578 | biostudies-arrayexpress
TranscriptomicsSystems Toxicology Identifies Mechanistic Impacts of 2-amino-4,6-dinitrotoluene (2-ADNT) Exposure in Northern Bobwhite
A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to pursue a holistic understanding of the effects of the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT) dosing on the health of the wildlife bird model, Northern bobwhi...
ORGANISM(S): Colinus virginianus 
2015-07-01 | E-GEOD-59910 | biostudies-arrayexpress
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