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MetabolomicsMultiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunction

An anaerobe-dominant, Lactobacillus-deplete cervicovaginal microbiome is associated with adverse reproductive outcomes. Gardnerella vaginalis, a cervicovaginal anaerobe, alters cervicovaginal epithelial cell function, resulting in immune activation and barrier breakdow...

2026-02-10 | MTBLS13885 | MetaboLights
MetabolomicsPolyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that has been found to additionally possess the ability to control tissue homeostasis a...

2025-07-24 | MTBLS12633 | MetaboLights
MetabolomicsAftpo3 and Afdur3, the Aspergillus fumigatus Plasma Membrane Transporters of Polyamines, Regulate Polyamine Homeostasis and Itraconazole Susceptibility

Aspergillus fumigatus is a notorious opportunistic pathogen that causes Invasive Aspergillosis (IA) infections with high mortality in immunosuppressed individuals. Long-term antifungal drug azole abuse in clinical treatment and agriculture renders it ineffectual or drug resistant. Drug resistance...

2020-12-21 | MTBLS1739 | MetaboLights
TranscriptomicsPolyamines induce the glutamate decarboxylase acid response system by increasing the level of the σ38 subunit (RpoS) of Escherichia coli RNA polymerase via gadE regulon
To study the physiological roles of polyamines, we have carried out a global microarray analysis on the effect of adding polyamines to an Escherichia coli mutant that lacks polyamines because of deletions in the genes in the polyamine biosynthetic pathway. Previously, we have reported that the earli...
ORGANISM(S): Escherichia coli 
2015-08-06 | E-GEOD-67119 | biostudies-arrayexpress
TranscriptomicsPolyamines are critical for the induction of the glutamate decarboxylase-dependent acid resistance system in Escherichia coli
As part of our studies on the biological functions of polyamines we have used a mutant of Escherichia coli that lacks all the genes for polyamine biosynthesis for a global transcription analysis on the effect of added polyamines. The most striking early response to polyamine addition is the increase...
ORGANISM(S): Escherichia coli 
2013-12-05 | E-GEOD-49918 | biostudies-arrayexpress
GenomicsSnapshot of translation in mammalian cells that are depleted of polyamines or replete with polyamines
Snapshot of translation in mammalian cells that are depleted of polyamines or replete with polyamines
PRJNA437287 | ENA
MetabolomicsSAR11 Cells Rely on Enzyme Multifunctionality to Transport and Metabolize a Range of Polyamine Compounds
In the ocean surface layer and cell culture, the polyamine transport protein PotD of SAR11 bacteria is often one of the most abundant proteins detected. Polyamines are organic cations at seawater pH produced by all living organisms and are thought to be an important component of dissolved organic ma...
2021-09-09 | MTBLS3146 | MetaboLights
GenomicsPolyamines buffer labile iron to suppress ferroptosis
Polyamines buffer labile iron to suppress ferroptosis
PRJNA1431983 | ENA
TranscriptomicsSnapshot of translation in mammalian cells that are depleted of polyamines or replete with polyamines
Snapshot of translation in mammalian cells that are depleted of polyamines or replete with polyamines. Hek293T cells treated with DFMO or Spermidine.
ORGANISM(S): Homo sapiens 
2018-10-11 | GSE111517 | GEO
ProteomicsPolyamines stimulate the protein synthesis of the initiation factor eIF5A2 participating in mRNA decoding distinct from eIF5A1
Polyamines are present in all living organisms, and their homeostasis is closely associated with human health and disease. Further, they are small aliphatic cations that exhibit multifunctional activities through interactions with acidic substances, thereby precluding our understanding of their mole...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD063151 | Pride
Polyamine Proteomics Eukaryotic initiation factor 5a (eif5a) Cell proliferation Spermidine 
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