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MetabolomicsMulti-omics analysis revealed spermidine contributes to ovarian function improvement
Spermidine is involved in extensive cellular processes, including mammalian oocyte development. Wheat germ is a natural source of polyamines and contains high concentrations of spermidine. No studies have assessed the effects and mechanisms of action of wheat germ spermidine in regulating mammalian ...
2024-10-28 | MTBLS11115 | MetaboLights
MetabolomicsMung bean (Vigna radiata L.) ethanol extracts alleviate alcoholic liver injury with modulation of gut microbiota and spermidine elevation

The pathophysiology of alcoholic-associated liver disease (ALD) is multifaceted. Utilizing the gut-liver axis framework and integrated multi-omics approaches, this study systematically evaluated the therapeutic potential of mung bean (Vigna radiata L.) ethanol extracts (MBE) in ALD, and its...

2025-10-10 | MTBLS13109 | MetaboLights
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae mutant delta-spe3 delta-fms1 after spermidine treatment
The naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have prominent regulatory roles in cell division and growth, precise molecular and cellular functions are not well established in vivo. In this work we have performed a microarray e...
ORGANISM(S): Saccharomyces cerevisiae 
2009-09-05 | E-GEOD-15269 | biostudies-arrayexpress
TranscriptomicsSpermidine Yeast Aging Array
Administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extends the lifespan of various model organisms including yeast, flies and worms. In ageing yeast, spermidine treatment triggeres epigenetic deacetylation of histone H3 through...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-04 | E-MTAB-912 | biostudies-arrayexpress
MetabolomicsAtg32-mediated mitophagy promotes heat stress tolerance in Saccharomyces cerevisiae by sustaining spermidine and nitric oxide levels
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST001318 | MetabolomicsWorkbench
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
TranscriptomicsHuman Hair follicles: Control Vs. 0.5 µM spermidine treatment
To compare the effects of spermidine, key polyamine, on the gene expression profile of organ cultured human hair follicles Vehicle treated Vs. 0.5 µM spermidine treatment. Two control samples, two spermidine treated samples
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28650 | biostudies-arrayexpress
ProteomicsMass spectrometry distinguishes putrescine, spermidine, and spermine covalently attached to proteins
Bacterial and mammalian cells are rich in putrescine, spermidine and spermine. Polyamines can be incorporated into proteins in vitro. Very few naturally occurring polyaminated proteins have been identified. Bovine albumin and the recombinant universal stress protein from Francisella tularensis we...
ORGANISM(S): Bos taurus (Bovine) 
2024-02-27 | PXD046396 | Pride
Polyamine Universal stress protein Transglutaminase Mass spectrometry Manual evaluation Carbodiimide Albumin 
TranscriptomicsTranscription profiling of mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT)
Type 2 diabetes is a complex disorder due to defects in insulin secretion and insulin action. Therefore, we investigated mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT) have reduced amount of white adipose tissue, high basal metabolic rate, improved glucose tolerance, high insul...
ORGANISM(S): Mus musculus 
2007-04-25 | E-MEXP-165 | biostudies-arrayexpress
ProteomicsThe analysis of spermidine-binding proteins
Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. This process is regulated by methionine metabolite spermidine，which can bind with proteins to regulate their biological function. Thus，the binding proteins of sp...
ORGANISM(S): Homo Sapiens 
2025-01-21 | PXD060003 |
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