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TranscriptomicsAlbumin, TGF-Beta1 and Blood-Brain Barrier opening induce cortical epileptogenesis.
Insults to the cerebral cortex, such as trauma, ischemia or infections, may result in the development of epilepsy, one of the most common neurological disorders. Previous studies have suggested that perturbations in neurovascular integrity and breakdown of the blood-brain barrier (BBB) lead to neuro...
ORGANISM(S): Rattus norvegicus 
2009-07-15 | E-GEOD-12304 | biostudies-arrayexpress
ProteomicsDefining albumin as a glycoprotein with multiple N-linked glycosylation sites
Background Plasma proteins can be modified by addition of sugar residues by non-enzymatic glycation as well as glycosylation. While glycation is a hallmark of hyperglycemia, glycosylation is a complex, enzyme-catalyzed post-translational modification by heterogeneous sugar chains and is present on ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) 
2024-06-16 | PXD047863 | Pride
Microheterogeneity Glycoproteomics Novel glycosylation site Hsa Human serum albumin Bsa 
ProteomicsQuantification of isoaspartate levels in human serum albumin of blood samples
We measured the isoaspartate levels in human serum albumin of blood samples from 20 patients with Alzheimer's disease and 20 healthy controls.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027563 | Pride
Mass spectrometry Isoaspartate Human serum albumin Alzheimer's disease 
ProteomicsThe C-terminal end of engineered albumin variants and fusion proteins after exposure to carboxypeptidase A
Albumin has a long plasma half-life due to engagement of the neonatal Fc receptor (FcRn), which prevents intracellular degradation. However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 2...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-19 | PXD063561 | Pride
Albumin engineering Carboxypeptidase a The neonatal fc receptor (fcrn) Albumin-fusion proteins 
TranscriptomicsTranscription profiling by array of human endothelial cell monolayers treated with homocysteinylated albumin
Endothelial cells monolayers were incubated, for 18h, in the presence of 1.0 ?M N-homocysteinylated albumin. Negative controls were cells incubated with unmodified human serum albumin at a comparable protein concentration and untreated cells.
ORGANISM(S): Homo sapiens 
2011-06-07 | E-MEXP-2771 | biostudies-arrayexpress
ProteomicsQuantification of glycated human serum albumin peptides
Human serum albumin is the most abundant plasma protein with a large number of lysine and arginine residues. Hence, it is highly susceptible to glycation in vivo. In hyperglycemic conditions, such as diabetes, the level of HSA glycation increases. Here we quantified glycated HSA peptides in a subjec...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040028 | Pride
Glycation Mass spectrometry Human serum albumin Hba1c Plasma Microalbuminuria Kidney Homo sapiens 
ProteomicsIdentification of Proteome Profile in Serum depleted albumin of Indian freshwater teleost, Labeo rohita (Hamilton)
The proteome of Serum depleted albumin of Indian freshwater teleost, Labeo rohita (Hamilton) was studied to understand protein expression.
ORGANISM(S): Labeo rohita (Indian major carp) 
2025-05-13 | PXD028387 | Pride
Freshwater fish Indian major carp Teleost Labeo rohita Fish Peptide Proteome Liquid chromatography mass spectroscopy 
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
ProteomicsIn-depth proteome analysis of Hela cell culture conditioned media containing fetal bovine serum.
We performed DIA-MS based proteomic analysis of Hela cells conditioned media containing fetal bovine serum by albumin (Alb)-depletion and non-depletion. In addition, we attempted to enrich secreted proteins by reducing the volume of culture medium (10mL, 5mL and 2mL). The supernatants of each cultur...
ORGANISM(S): Homo Sapiens (human) 
2022-02-22 | PXD024272 | JPOST Repository
ProteomicsQuantification of glycated rat serum albumin peptides
Serum albumin is the most abundant plasma protein with a large number of lysine and arginine residues. Hence, it is highly susceptible to glycation, a non-enzymatic reaction involving binding of non-reducing sugars to proteins, in vivo. Oxidative stress is known to promote glycation and the Advanced...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-29 | PXD074495 | Pride
Glycation Swath-mass spectrometry Serum Albumin peptides Middle-aged rats 
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