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MetabolomicsCrosstalk between S-nitrosylation and glycation defines a novel metabolic vulnerability in liver and renal cancers

Metabolic reprogramming is a defining feature of cancer; however, how it contributes to therapeutic resistance remains incompletely understood. Here we show that loss of aldo-ketoreductase 1A1 (AKR1A1) in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) disrupts terminal glycolytic f...

2026-07-10 | MTBLS15003 | MetaboLights
ProteomicsAdvanced glycation end products as markers of ageing in plants: glycation hotspots in the plant proteome
Glycation is a post-translational modification underlied by the interaction of protein amino and guanidino groups with carbonyl compounds like reducing sugars and α-dicarbonyls. In the first steps of this process, the protein amino groups react with reducing carbohydrates yielding the corresponding ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-06-19 | PXD006434 | Pride
Ages Plant proteomics Glycation 
ProteomicsHuman holo-transferrin glycation
Understanding the effect of glycation on the function of transferrin, the systemic iron transporter, is fundamental to fully grasp the mechanisms leading to the loss of iron homeostasis observed in diabetes mellitus (DM). The spontaneous reaction with protein amino groups is one of the main causes o...
ORGANISM(S): Homo sapiens (Human) 
2018-05-30 | PXD009345 | Pride
Post-translational modification Holo-transferrin Blood serum Glycation Lc-ms/ms 
ProteomicsThe oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
The NRF2 transcription factor controls a cell stress program that is implicated in cancer and there is great interest in targeting NRF2 for therapy. We show that NRF2 activity depends on Fructosamine-3-kinase (FN3K) - a kinase that triggers protein de-glycation. In its absence, NRF2 is extensively g...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-07-08 | PXD014334 | Pride
Hepatocellular carcinoma (hcc) Age Glycation Fn3k Nrf2 
ProteomicsRegion-selective and site-specific glycation of influenza proteins surrounding the viral envelope membrane
Analysis of protein modifications is critical for quality control of therapeutic biologics. We used highly sensitive LC MS/MS analyses combined with multiple enzyme digestions to determine low abundance early-stage lysine glycation products of influenza vaccines derived from embryonated chicken eggs...
ORGANISM(S): Influenza A virus (A/turkey/Italy/3466/1999(H7N1)) 
2024-10-17 | PXD052096 | Pride
Influenza vaccine Glycation Mass spectrometry 
ProteomicsGlycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson’s disease (PD) ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD032832 | Pride
Brain Parkinson's disease Glycation 
ProteomicsPitfalls and Solutions in Mass Spectrometry-based Identification of Protein Glycation
Protein glycation is a type of post-translational modification (PTM) involving complex non-enzymatic reactions of reducing sugars or reactive dicarbonyls with proteins, generating a heterogeneous group of advanced glycation end-products (AGEs) such as carboxymethyllysine (CML). In bottom-up proteomi...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-01-24 | PXD032235 | Pride
Cam Post-translational modification Human Iaa N-isopropylcarbamidoethylation Nipam Cm Cml Cell line Q-exactive N-isopropylacrylamide Hela 2-iodoacetamide Orbitrap Carboxymethylation Escherichia coli E. coli Ptm Kidney Protein glycation Hek293 Carboxymethyllysine Lc-ms/ms Age Nipcae Carbamidomethylation Advanced glycation end-product 
ProteomicsBovine protein glycation sites in different milk products
Here we studied the glycation of bovine milk proteins by lactose as dominant sugar in milk and hexoses using tandem mass spectrometry (CID and ETD mode). In a bottom-up proteomics approach after enriching glycated peptides by boronate affinity chromatography, first we could identify 260 lactosylated...
ORGANISM(S): Bos taurus (Bovine) 
2016-01-11 | PXD003054 | Pride
Electron transfer dissociation (etd) Infant formula Maillard reaction Boronate affinity chromatography (bac) Lactose-free milk Nrpc-esi-ms/ms Non-enzymatic glycosylation 
ProteomicsAn azidoribose probe to track ketoamine adducts in histone ribose glycation (293T nuclei - LFQ)
Reactive cellular metabolites can modify macromolecules and form adducts known as non-enzymatic covalent modifications (NECMs). Dissecting the mechanisms, regulation and consequences of NECMs, such as glycation, has been challenging due to the complex and often ambiguous nature of the adducts formed...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD019204 | Pride
Glycation Proteomics Ribose Epigenetics Histones Click chemistry 
GenomicsGlycation-mediated tissue-level remodeling of brain meningeal membrane by aging
Glycation-mediated tissue-level remodeling of brain meningeal membrane by aging
PRJNA892952 | ENA
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