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ProteomicsProteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1
Gaucher disease (GD) is caused by the defective activity of acid beta-glucosidase (GCase) which results from mutations in GBA1. Neurological forms of GD (nGD) can be generated in mice by intra-peritoneal injection of conduritol B-epoxide (CBE) which irreversibly inhibits GCase. Using this approach, ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-12 | MSV000092415 | MassIVE
ProteomicsIdentification of Isopeptides Between Human Tissue Transglutaminase and Wheat, Rye, and Barley Gluten Peptides
Celiac disease (CD) is a chronic immune-mediated enteropathy of the small intestine, which is triggered by the ingestion of storage proteins (gluten) from wheat, rye, and barley in genetically predisposed individuals. Human tissue transglutaminase (TG2) plays a central role in the pathogenesis of CD...
ORGANISM(S): Homo Sapiens Triticum Aestivum Secale Cereale Hordeum Vulgare 
2020-08-27 | PXD017693 | panorama
TranscriptomicsTranscription profiling of sputum samples from individuals exercise-induced bronchoconstriction (EIB).
Asthma is a heterogeneous disease. Exercise-induced bronchoconstriction (EIB) is a distinct syndrome that occurs in 30-50% of asthmatics and is characterized by high levels of pro-inflammatory eicosanoids. We identified genes differentially expressed in the airways of asthmatics with EIB relative to...
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-13785 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of ATRA-differentiated wild-type and TG2 knockout NB4 cells
Treatment of acute promyelocytic leukemia (APL) with all-trans-retinoic acid (ATRA) results in terminal differentiation of leukemic cells toward neutrophil granulocytes. Administration of ATRA leads to massive changes in gene expression, including down-regulation of cell proliferation-related genes ...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-23702 | biostudies-arrayexpress
ProteomicsMapping of transglutaminase 2 active sites of human salivary small basic proline-rich
Due to the distinctive features of oral mucosa, determination of the proteins involved in the formation of “oral protein pellicle” is demanding. The present study investigated the susceptibility of several human basic proline-rich peptides (bPRPs) named P-H, P-D, P-F, P-J, and II-2 as substrates of ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-25 | PXD014658 | Pride
Bprps Saliva Transglutaminase 2 Human 
ProteomicsComprehensive detection of isopeptides between human tissue transglutaminase and gluten peptides using a reciprocal proteomic approach
Celiac disease (CD) is a chronic inflammation of the small intestine triggered by the ingestion of gluten in genetically predisposed individuals. Tissue transglutaminase (TG2) is a key factor in the pathogenesis of CD, because it catalyzes both the deamidation of specific glutamine residues and the ...
ORGANISM(S): Homo sapiens (Human) Triticum aestivum (Wheat) 
2019-09-27 | PXD014067 | Pride
Celiac disease  transglutaminase  isopeptides  gluten 
ProteomicsMass spectrometry distinguishes putrescine, spermidine, and spermine covalently attached to proteins
Bacterial and mammalian cells are rich in putrescine, spermidine and spermine. Polyamines can be incorporated into proteins in vitro. Very few naturally occurring polyaminated proteins have been identified. Bovine albumin and the recombinant universal stress protein from Francisella tularensis we...
ORGANISM(S): Bos taurus (Bovine) 
2024-02-27 | PXD046396 | Pride
Polyamine Universal stress protein Transglutaminase Mass spectrometry Manual evaluation Carbodiimide Albumin 
ProteomicsInfection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis
Transglutaminase 2 (TG2) is a ubiquitous enzyme with transamidating activity. We report here that the expression and activity of TG2 are enhanced in cells infected with the obligate intracellular bacteria Chlamydia trachomatis. Genetic or pharmacological inhibition of TG2 activity impair bacterial d...
ORGANISM(S): Homo sapiens (Human) Chlamydia trachomatis E/C599 
2020-02-25 | PXD017117 | Pride
Chlamydia Hexosamine biosynthesis O-glcnacylation Gfpt Transglutaminase 2 
GenomicsTissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages
Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages
PRJNA918974 | ENA
ProteomicsIdentification of human transglutaminase 4 substrates in AD-293 protein extract by biotin-pentylamine incorporation
We have identified cellular substrates of human transglutaminase 4 (TG4) by LC-MS/MS-based method from transglutaminase negative AD-293 cell line. Recombinant human TG4 dependent biotin pentylamine (BPA) modified peptides/proteins were detected from cytoplasmic (Cp) and nuclear (N) protein fractions...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-27 | MSV000088030 | MassIVE
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