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ProteomicsInfection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis
Transglutaminase 2 (TG2) is a ubiquitous enzyme with transamidating activity. We report here that the expression and activity of TG2 are enhanced in cells infected with the obligate intracellular bacteria Chlamydia trachomatis. Genetic or pharmacological inhibition of TG2 activity impair bacterial d...
ORGANISM(S): Homo sapiens (Human) Chlamydia trachomatis E/C599 
2020-02-25 | PXD017117 | Pride
Chlamydia Hexosamine biosynthesis O-glcnacylation Gfpt Transglutaminase 2 
UnknownInfection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells.
Not available
S-EPMC7156965 | biostudies-literature
UnknownGFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Not available
S-EPMC8970586 | biostudies-literature
UnknownDifferential hexosamine biosynthetic pathway gene expression with type 2 diabetes.
Not available
S-EPMC5121314 | biostudies-literature
UnknownAbnormal decrement on high-frequency repetitive nerve stimulation in congenital myasthenic syndrome with GFPT1 mutations and review of literature.
Not available
S-EPMC9520358 | biostudies-literature
UnknownInfection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells
Not available
S-SCDT-EMBOJ-2019-102166 | biostudies-other
UnknownTranscriptomic and Metabolomic Analyses Reveal the Differential Regulatory Mechanisms of Compound Material on the Responses of Brassica campestris to Saline and Alkaline Stresses.
Not available
S-EPMC8905141 | biostudies-literature
UnknownRELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection.
Not available
S-EPMC9319012 | biostudies-literature
TranscriptomicsChanges in global gene expression in SIN1 knock-out murine epithelial fibroblasts
RNA from wt and SIN1 knock-out MEF cell lines were compared Using affymetrix murine gene chip, the effects of SIN1 ablation on global gene transcription were assessed RNA from wild type and SIN1 knock out cells was purified and differences in gene expression between the two sets. MEFs were derived f...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-65464 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mesangial cell line MES-13 to examine the global effects of high glucose (HG) and glucosamine (GlcN) on the transcriptome.
The renal mesangial cells play an important role in the development of diabetic glomerulosclerosis and renal failure. We have previously demonstrated some of the effects of high glucose are mediated via the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosami...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2557 | biostudies-arrayexpress
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