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MetabolomicsImpact of oral Chlamydia Vaccination on Host Gut Microbiome and Metabolite Composition

Chlamydia trachomatis, an intracellular pathogen, is recognized as the most common sexually transmitted bacterial infection among women worldwide. Chlamydia infections can lead to undesirable clinical outcomes, including pelvic inflammatory disease and infertility. Recently, the gut has been...

2025-11-07 | MTBLS12603 | MetaboLights
MetabolomicsIdentification of metabolites of trifunctional sphingomyelin (TFSM1) in HeLa 229 cells infected with Chlamydia trachomatis

Chlamydia trachomatis is an obligate intracellular bacterial pathogen and a leading cause of sexually transmitted infections worldwide. During its biphasic developmental cycle, infectious, non-replicative elementary bodies alternate with replicative reticulate bodies within a membrane-bound intra...

2026-08-10 | MTBLS15303 | MetaboLights
TranscriptomicsComparison of mouse macrophages and reproductive tract epithelial cells at baseline and in an inflammatory milieu mimicking a Chlamydia genital tract infection
Chlamydia trachomatis urogenital serovars are intracellular bacteria that parasitize human reproductive tract epithelium. As the principal cell type supporting bacterial replication, epithelial cells are central to Chlamydia immunobiology initially as sentries and innate defenders, and subsequently...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-74317 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse C57BL6J and DBA2J strains when Chlamydia infected
C57BL/6J mice were 105-fold more resistant to Chlamydia psittaci infection than DBA/2J mice by LD100 determinations. Linkage analysis using BXD recombinant inbred strains revealed a single effector locus at a 1.5 Mbp region on chromosome 11 encoding a cluster of three p47GTPases (Irgb10, Igtp, and I...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7767 | biostudies-arrayexpress
TranscriptomicsExpression data of A2EN cells during early stage of Chlamydia trachomatis infection
Chlamydia trachomatis is an obligate intracellular pathogen that causes trachoma and sextually transmitted disease in human. During early stage of infection, Chlamydia secreted bacterial effector proteins into host cell cytoplasm to help its entry and estabilishment of early replicated niche. We ide...
ORGANISM(S): Homo sapiens 
2014-04-09 | E-GEOD-54336 | biostudies-arrayexpress
ProteomicsProtein profiling of Chlamydia trachomatis growth forms
By comprehensive quantitative proteome analysis we characterize the three growth forms elementary body (EB), reticulate body (RB) and aberrant reticulate body (ARB) of Chlamydia trachomatis genital strain D/UW-3/CX
ORGANISM(S): Chlamydia trachomatis (strain D/UW-3/Cx) 
2017-01-04 | PXD003883 | Pride
Rb Lc-msms Chlamydia trachomatis Eb Arb 
TranscriptomicsPlac8-dependent and iNOS-dependent T cell-mediate mechanisms clear Chlamydia muridarum infections from the genital tract
Comparison of two Chlamydia-specific CD4 T cells that are dependent on iNOS to terminate Chlamydia replication in epithelial cells to two Chlamydia-specific CD4 T cells that are iNOS-independent: Chlamydia trachomatis urogenital serovars replicate predominately in epithelial cells lining the reprod...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-32128 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of Chlamydia trachomatis Serovar D genes under different in-vitro hormonal conditions
In this project we examined in-vitro effect of female sex hormones, estradiol and progesterone at average physiological concentration level on Chlamydia trachomatis gene expression level. Regulation of chlamydial gene expression by the female sex hormones oestradiol and progesterone was examined. A ...
ORGANISM(S): Chlamydia trachomatis 
2010-09-16 | E-GEOD-24119 | biostudies-arrayexpress
TranscriptomicsDevelopmental stage specific metabolic and transcriptional activity of chlamydial elementary bodies and reticulate bodies in an axenic medium
Chlamydia trachomatis is a significant human pathogen yet their obligate intracellular nature severe restrictions upon research. Chlamydiae undergo a complex developmental cycle characterized by an infectious cell type known as the elementary body (EB) and an intracellular active replicative form ...
ORGANISM(S): Chlamydia trachomatis 
2012-11-20 | E-GEOD-39530 | biostudies-arrayexpress
ProteomicsIntegrated phosphoproteome and transcriptome analysis reveals Chlamydia-induced epithelial-to-mesenchymal transition in host cells
Chlamydia trachomatis are the etiological agents of a range of diseases and are epidemiologically associated with cervical and ovarian cancers. The interplay between host and chlamydia is highly complex, and to obtain panoramic view of the functional interplay, we performed combinatorial global phos...
ORGANISM(S): Homo sapiens (Human) 
2018-12-07 | PXD011960 | Pride
Chlamydia Phosphoproteomics 
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