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This study aimed to explore the potential of serum proteomics as a non-invasive diagnostic tool using MALDI-TOF mass spectrometry (MS) combined with machine learning techniques. We analyzed serum samples from 269 patients, employing machine learning models to differentiate between healthy individual...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD060922 | Pride
Various cancers such as colorectal cancer (CRC) are associated with alterations in protein glycosylation. CRC cell lines are frequently used to study these (glyco)biological changes and their mechanisms. However, differences between CRC cell lines with regard to their glycosylation have hitherto bee...
2017-02-03 | MTBLS227 | MetaboLights
Gel based approach : Concanavalin A bound fiber glycoproteins were resolved through SDS PAGE followed by identification of trypsinised gel pieces through Nano-LC MALDI TOF/TOF. Solution based approach: Concanavalin A bound fiber glycoproteins were solution phase digested and fractionated through SC...
ORGANISM(S): Gossypium 
2014-03-18 | PXD000178 | Pride
Glycoproteins isolated from elongating cotton fiber cells were analyzed using 2D-PAGE followed by MALDI TOF/TOF based protein identification. Protein isoforms were identified using Tandem mass spectrometry. Lectin based Glycopeptide enrichment strategy followed by PNGase catalyzed deglycosylation re...
ORGANISM(S): Gossypium 
2015-11-25 | PXD002849 | Pride
Introduction The identification of proteins involved in brain ischemia might allow the discovery of new putative biomarkers or potential therapeutic target of one of the most important neurological disorders. MALDI Imaging-Mass-Spectrometry (IMS) is a powerful technique that allows the visualization...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-14 | PXD003644 | Pride
SARS-CoV-2 infection poses a worldwide public health problem affecting millions of people worldwide. There is a critical need for improvements in the noninvasive prognosis of COVID-19. We hypothesized that matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF MS) analysis combined...
ORGANISM(S): Homo sapiens (Human) 
2021-06-22 | PXD021581 | Pride
There are no widely-accepted prognostic markers currently available to predict outcomes in patients with triple-negative breast cancer (TNBC), and no targeted therapies with confirmed benefit. We have used MALDI mass spectrometry imaging (MSI) of tryptic peptides to compare regions of cancer and ben...
ORGANISM(S): Homo sapiens (Human) 
2019-05-06 | PXD013397 | Pride
Experimental autoimmune encephalomyelitis (EAE) is a murine model of multiple sclerosis, a chronic neurodegenerative and inflammatory autoimmune condition of the central nervous system (CNS). Pathology is driven by the infiltration of autoreactive CD4+ lymphocytes into the CNS where they attack neur...
ORGANISM(S): Mus musculus (Mouse) 
2016-07-08 | PXD001011 | Pride
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