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MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
TranscriptomicsSTRT RNAseq of THP-1 monocytic cells exposed to surface modified-gold nanoparticles
Transcriptome comparison to assess the responses of human monocytic cells (THP-1) to gold-nanoparticles (Au-NPs) of two different diameter sizes (5 or 20 nm) with different surface functional groups, i.e., alkylammonium bromide, alkyl sodium carboxylate, or poly(ethylene glycol) (PEG)-terminated thi...
ORGANISM(S): Homo sapiens 
2019-06-04 | E-MTAB-7093 | biostudies-arrayexpress
TranscriptomicsMechanisms of response to silver nanoparticles Enchytraeus albidus (Oligochaeta): survival, reproduction and gene expression profile
Due to its antimicrobial activity, silver nanoparticles (Ag-NPs) are among the most used NPs worldwide, yet little information is available regarding their effects, particularly in soil dwelling organisms. Enchytraeids (Oligochaeta) are important members of the soil fauna which actively contribute t...
ORGANISM(S): Enchytraeus albidus 
2013-05-22 | E-GEOD-42431 | biostudies-arrayexpress
ProteomicsBV-2 cells treated with different nanoparticles
BV-2 cells treated with different nanoparticles,including rHDL,PEG-PLA NPs,QD,PEG-QD and AuNP.The cells were treated with NPs for 4h.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-01 | PXD044395 | Pride
Nanoparticles Microglia 
TranscriptomicsSilica nanoparticles effects on gene expression of A549 cells
Expansion of nanotechnology will bring many potential benefits as adversely effects on human health. Protection of the human respiratory system from exposure of volatile nanoparticles has become an emerging health concern. The understanding of the biological processes involved in the development and...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-53700 | biostudies-arrayexpress
TranscriptomicsToxicogenomic responses of C. elegans to gold nanoparticles
We used Au nanoparticles (Au-NPs) as a model for studying particle specific effects of manufactured nanomaterials (MNMs) by examining the toxicogenomic responses in a model soil organism, free living nematode Caenorhabditis elegans. Global genome expression for nematodes exposed to 4-nm citrate-coat...
ORGANISM(S): Caenorhabditis elegans 
2012-04-15 | E-GEOD-32521 | biostudies-arrayexpress
ProteomicsInsights into the proteomic response of soybean to stress of Al2O3, ZnO, and Ag nanoparticles
The present study highlights the phytotoxicity of nanoparticles (NPs) to soybean roots and leaves at proteome level. The effect of three NPs Al2O3, ZnO, and Ag suspensions on soybean was evaluated.
ORGANISM(S): Glycine max 
2015-11-16 | PXD001923 | Pride
Nanoparticles Proteomics Zno-nps Al2o3-nps Ag-nps Oxidative stress Soybean 
TranscriptomicsRNAseq of human epithelial lung carcinoma cell line A549 exposed to ceria, silver or zinc ions, micron-sized particles or nanoparticles
The toxicity of silver and zinc oxide nanoparticles is hypothesised to be mediated by dissolved metal ions and cerium dioxide nanoparticles (CeO2 NPs) are hypothesised to induce toxicity specifically by oxidative stress dependant on their surface redox state. To test these hypotheses, RNAseq was app...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-5734 | biostudies-arrayexpress
TranscriptomicsGene expression profile of human endothelial cells with or without nanoparticles
To understand the the effect of poly(lactic-co-glycolic acid) nanoparticles (NPs) encapsulating a fluorine contrast agent on human umbilical vein endothelial cells (HUVECs), we have employed whole genome microarray expression profiling. The NPs used in this study were prepared in our lab. HUVECs wer...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-51661 | biostudies-arrayexpress
TranscriptomicsGene expression profile of hematopoietic stem cells (CD34+ cells) with or without nanoparticles
To understand the the effect of poly(lactic-co-glycolic acid) nanoparticles (NPs) encapsulating a fluorine contrast agent on hematopoietic stem cells (CD34+ fraction of umbilical cord blood mononuclear cells), we have employed whole genome microarray expr The gene expression in human CD34+ cells was...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-51421 | biostudies-arrayexpress
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