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UnknownThe impact of depression, anxiety and stress on self-care in inflammatory bowel disease: a systematic review.
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, compromises both physical and psychological health. High levels of stress, anxiety, and depression are common yet often overlooked, negatively impacting treatment adherence and self-care. This review examines how psy...
S-EPMC12850693 | biostudies-literature
UnknownGilteritinib and the risk of intracranial hemorrhage: a case series of a possible, under-reported side effect.
Gilteritinib is currently approved for patients with relapsed/refractory AML with FLT3 mutations, based on the positive results of the pivotal ADMIRAL study. In ADMIRAL trial, no increased risk of bleeding was reported, but in the previous dose finding study, a single event of intracranial hemorrhag...
S-EPMC10567884 | biostudies-literature
UnknownRobot-assisted retroperitoneal lymph node dissection in testicular cancer: state of the art and future perspectives.
Not available
S-EPMC12748088 | biostudies-literature
UnknownHow Immunotherapy Has Changed the Continuum of Care in Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) is one of the leading causes of death worldwide. The use of local treatment, such as surgical resection, liver transplant, and local ablation, has improved the survival of patients with HCC detected at an early stage. Until recently, the treatment of patients with meta...
S-EPMC8466991 | biostudies-literature
UnknownThrombopoietin receptor agonists in adult Evans syndrome: an international multicenter experience.
Not available
S-EPMC9389636 | biostudies-literature
UnknownTreatment for preventing tuberculosis in children and adolescents: a randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and isoniazid.

Importance

Three months of a once-weekly combination of rifapentine and isoniazid for treatment of latent tuberculosis infection is safe and effective for persons 12 years or older. Published data for children are limited.

Objectives

To compare treatment safety and assess noninferiori...
S-EPMC6624831 | biostudies-literature
UnknownAutoimmune hemolytic anemia during pregnancy and puerperium: an international multicenter experience.
Relapsing or occurring de novo autoimmune hemolytic anemia (AIHA) during pregnancy or puerperium is a poorly described condition. Here, we report 45 pregnancies in 33 women evaluated at 12 centers from 1997 to 2022. Among the 20 women diagnosed with AIHA before pregnancy, 10 had a relapse. An additi...
S-EPMC10646778 | biostudies-literature
UnknownTFEB AND TFE3 CONTROL GLUCOSE HOMEOSTASIS BY REGULATING INSULIN GENE EXPRESSION.
To fulfil their function, pancreatic beta-cells require precise nutrient sensing mechanisms that control insulin production. Transcription Factor EB (TFEB) and its homologue TFE3 have emerged as crucial regulators of the adaptive response of cell metabolism to environmental cues. Here we show that T...
S-SCDT-10_15252-EMBJ_2023113928 | biostudies-other
UnknownTrial of short-course antimicrobial therapy for intraabdominal infection.

Background

The successful treatment of intraabdominal infection requires a combination of anatomical source control and antibiotics. The appropriate duration of antimicrobial therapy remains unclear.

Methods

We randomly assigned 518 patients with complicated intraabdominal infection a...
S-EPMC4469182 | biostudies-literature
UnknownComparison of "IN-REC-SUR-E" and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial).

Background

Surfactant is a well-established therapy for preterm neonates affected by respiratory distress syndrome (RDS). The goals of different methods of surfactant administration are to reduce the duration of mechanical ventilation and the severity of bronchopulmonary dysplasia (BPD); how...
S-EPMC11218154 | biostudies-literature
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