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Organelles like lysosomes and synaptic vesicles are acidified by V-ATPases, which consist of a cytosolically-oriented V1 complex that hydrolyzes ATP and a membrane-embedded VO complex that pumps protons. In yeast, V1-VO association is facilitated by the RAVE complex, but how higher eukaryotes assemb...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD064067 | Pride
Genome wide DNA methylation profiling of post-mortem human brain samples from both autistic individuals and nonautistic individuals. Samples of the frontal cortex (BA10) and cingulate cortex (BA24) were examined from each individual. Bisulphite converted DNA from the 45 samples were hybridised to ...
ORGANISM(S): Homo sapiens 
All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-mediated disruption by excising these TEs from host mRNAs. SOS splicing, which operates independently of...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD068578 | Pride
H3K4me3 ChIP-Seq profiling of a directed differentiation time course converting human embryonic stem cells (hES) into immature pancreatic beta cell precursors. CyT49, a Viacyte proprietary male hESC line with normal karyotype was used.
ORGANISM(S): Homo sapiens 
Transcriptional profiling of a directed differentiation time course converting human embryonic stem cells (hES) into immature pancreatic beta cell precursors.
ORGANISM(S): Homo sapiens 
In arthropods, hemolymph carries immune cells and solubilizes and transport nutrients, hormones, and other molecules that are involved in diverse physiological processes including immunity, metabolism and reproduction. However, despite such physiological importance, little is known about its composi...
ORGANISM(S): Aedes aegypti 
2026-07-06 | PXD047714 | Pride
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