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Genome wide DNA methylation profiling of post-mortem human brain samples from both autistic individuals and nonautistic individuals. Samples of the frontal cortex (BA10) and cingulate cortex (BA24) were examined from each individual. Bisulphite converted DNA from the 45 samples were hybridised to ...
ORGANISM(S): Homo sapiens 
All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-mediated disruption by excising these TEs from host mRNAs. SOS splicing, which operates independently of...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD068578 | Pride
Organelles like lysosomes and synaptic vesicles are acidified by V-ATPases, which consist of a cytosolically-oriented V1 complex that hydrolyzes ATP and a membrane-embedded VO complex that pumps protons. In yeast, V1-VO association is facilitated by the RAVE complex, but how higher eukaryotes assemb...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD064067 | Pride
RGS10L phosphorylatin site was determined. Trypsin is not good for generating a peptide containing the potential site, and the initial study was done using the intact protein. From the Top-Down study, the phosphorylatin site of the A->S variant was ambiguous. The firnal confirmation was done usin...
ORGANISM(S): Mus musculus (Mouse) Escherichia coli 
2021-11-03 | PXD023753 | Pride
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