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MetabolomicsIDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therapeutic strategies. Using proteomics and transcriptomic pro...

2026-01-14 | MTBLS11531 | MetaboLights
MetabolomicsClinacanthus nutans fractions exert anti-nasopharyngeal carcinoma effects: integrating untargeted metabolomics, network pharmacology, molecular docking and experimental validation

Background: Clinacanthus nutans (C. nutans), a Southeast Asian medicinal herb, has ethnopharmacological potential against nasopharyngeal carcinoma (NPC). This study aimed to elucidate the bioactive compounds, potential molecular targets, and regulatory pathways responsible for the anticancer acti...

2026-01-05 | MTBLS13610 | MetaboLights
TranscriptomicsHuman nasopharyngeal carcinoma
To uncover the oncogenic pathways of nasopharyngeal carcinoma, gene expression profiles of primary NPC cell strains and NPC-derived cell lines were conducted and analyzed in depth. Keywords: Oncogenesis Gene expression profiles of 9 primary NPC cell strains and 5 NPC-derived cell lines were analyz...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-14262 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human nasopharyngeal carcinoma vs control
Nasopharyngeal carcinoma is an Epstein-Barr virus-associated epithelial cancer with high prevalence in Southeast Asia. mRNA expression levels were measured for essentially all human genes and all latent Epstein-Barr virus (EBV) genes in nasopharyngeal carcinoma tissue samples and normal nasopharynge...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12452 | biostudies-arrayexpress
TranscriptomicsMicroRNA Signatures Correlate with Diagnosis, Distant Metastasis and Prognosis in nasopharyngeal carcinoma
microRNA signatures with diagnosis, distant metastasis and prognosis for nasopharyngeal carcinoma 62 nasopharyngeal carcinoma and 6 non-cancer nasopharyngitis fresh tissues were detected by microRNA microarray
ORGANISM(S): Homo sapiens 
2012-05-09 | E-GEOD-36682 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of nasopharyngeal carcinoma cell line HNE2 following TP53 overexpression
Recent studies have revealed that long non-coding RNAs (lncRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the epigenetic, transcriptional and post-transcriptional levels. LncRNAs are in turn regulated by other genes, forming a complex regula...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-60379 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of DNA methylation between nasopharyngeal carcinoma tissues and normal nasopharyngeal epithelial tissues
Nasopharyngeal carcinoma (NPC) is rare malignancy in most parts around the world but common in Southern China and Southeast Asia, Annually, approximately 80,000 new NPC cases and 50,000 deaths are reported worldwide. In NPC, recent advances have shown that many genes that are predominantly or even e...
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-52068 | biostudies-arrayexpress
Transcriptomicsnasopharyngeal carcinoma versus nasopharyngeal phlogistic tissue reference
Nasopharyngeal carcinoma (NPC) remains a majoy health problem worldwide, specially in Southeast China. In order to find the new candidate genes and molecular markers that are associated with nasopharyngeal carcinoma (NPC), this study focused on the screening NPC relative genes by gene expression pro...
ORGANISM(S): Homo sapiens 
2009-04-21 | E-GEOD-11219 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human biopsies of Nasopharyngeal carcinoma (NPC) and non-malignant controls
Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and South East Asia where more than 50,000 new cases are diagnosed each year. We used microarrays to identify down or upregulated genes in NPC compared with non-malignant controls. Experiment Overall Design: Snap frozen nasopharynge...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-GEOD-13597 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of nasopharyngeal carcinoma model system (mRNA)
Nasopharyngeal carcinoma (NPC) is a prevalent malignancyt disease in Southeast Asia among the Chinese population. Aberrant regulation of transcripts has been implicated in many types of cancers including NPC. Herein, we characterized mRNA and miRNA transcriptomes by RNA sequencing (RNASeq) of NPC mo...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54159 | biostudies-arrayexpress
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