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ProteomicsN-Acetyltransferase (NAT) 1 and NAT2 Enzyme Activities Drive Interindividual Variability in Sulfamethoxazole N-Acetylation
Sulfamethoxazole (SMX) is associated with idiosyncratic drug induced liver injury (DILI), which remains difficult to predict. SMX is primarily metabolized by the N-acetyltransferases NAT1 and NAT2 to form N4-acetyl sulfamethoxazole (NA-SMX) and by cytochrome P450-mediated oxidation to form SMX-hydro...
ORGANISM(S): Homo sapiens (Human) 
2025-12-06 | PXD066786 | Pride
UnknownFunctional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.
Not available
S-EPMC6208141 | biostudies-literature
UnknownFunctional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.
Not available
S-EPMC3271262 | biostudies-literature
TranscriptomicsNat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells [expression]
Nat1 (also known as p97/Dap5/Eif4g2) is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (also known as Eif4g1). We previously showed that Nat1-null mouse embryonic stem cells (mESCs) were resistant to differe...
ORGANISM(S): Mus musculus 
2017-01-06 | GSE89007 | GEO
TranscriptomicsNat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells [ribosome profiling]
Nat1 (also known as p97/Dap5/Eif4g2) is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (also known as Eif4g1). We previously showed that Nat1-null mouse embryonic stem cells (mESCs) were resistant to differe...
ORGANISM(S): Mus musculus 
2017-01-06 | GSE89011 | GEO
TranscriptomicsNat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells [expression 2]
Nat1 (also known as p97/Dap5/Eif4g2) is a ubiquitously expressed cytoplasmic protein that is homologous to the c-terminal two thirds of eukaryotic translation initiation factor 4G (also known as Eif4g1). We previously showed that Nat1-null mouse embryonic stem cells (mESCs) were resistant to differe...
ORGANISM(S): Mus musculus 
2017-01-06 | GSE89600 | GEO
GenomicsHomo sapiens
NAT1 gene methylation sequencing
PRJNA706559 | ENA
ProteomicsProteomic Analysis of Arylamine N-Acetyltransferase 1 Knockout Breast Cancer Cells
Description A phase II metabolic enzyme, NAT1 is frequently upregulated in breast cancers. Previous studies have shown that inhibition or depletion of NAT1 in breast cancer cell lines leads to growth retardation both in vitro and in vivo, suggesting that NAT1 contributes to rapid growth of breast ca...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035953 | Pride
Breast cancer Nat1 Mda Tmt10plex 
UnknownNAT1/DAP5/p97 and atypical translational control in the Drosophila Circadian Oscillator.
Not available
S-EPMC3522168 | biostudies-literature
UnknownNat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice.
Not available
S-EPMC5097870 | biostudies-literature
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