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TranscriptomicsExpression data from E13.5 Fz4-/- and Fz4+/+ kidneys
Fz4 and Fz8 cooperate in regulating the branching morhpogenesis of the developing kidney during mouse embryonic development, hence determines the eventual kidney size. We used microarrays to study the global gene expression profiles regulated by Fz4 and Fz8 signaling during early kidney development,...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-23781 | biostudies-arrayexpress
TranscriptomicsExpression data from E13.5 Fz4-/-Fz8-/- and Fz4+/+Fz8-/- kidneys
Fz4 and Fz8 cooperate in regulating the branching morhpogenesis of the developing kidney during mouse embryonic development, hence determines the eventual kidney size. We used microarrays to study the global gene expression profiles regulated by Fz4 and Fz8 signaling during early kidney development,...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-26668 | biostudies-arrayexpress
TranscriptomicsEndothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here we report that constitutive over-expression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell (EC) migration across the retinal surfac...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50059 | biostudies-arrayexpress
TranscriptomicsThe transcriptional response to Norrin/Fz4 signaling
Using mice with targeted gene mutations, we identify (1) distinct roles for different canonical Wnt signaling components in central nervous system (CNS) vascular development and in the specification of the blood-brain and blood-retina barriers (BBB and BRB) and (2) differential sensitivities of the ...
ORGANISM(S): Mus musculus 
2014-06-05 | E-GEOD-56461 | biostudies-arrayexpress
TranscriptomicsLong-term effect on the transcriptome of loss of Frizzled4 signaling in cerebellar endothelial cells
Transcriptional profiles of the cerebellar endothelial cells from P16 Fz4-/- animals were compared to their wild type littermate controls. The goal is to characterize the long-term effect on the transcriptome of loss of Fz4 signaling in cerebellar endothelial cells. Endothelial cells were immuno-pur...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-16707 | biostudies-arrayexpress
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