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MetabolomicsLipidomic analysis of Toxoplasma gondii extracellular vesicles across host cell types

Introduction. Toxoplasma gondii is an obligate intracellular parasite with an exceptional capacity to colonize a broad range of host species and cell types. Successful infection depends on its ability to manipulate host metabolism, including lipid pathways that are essential for membrane biogenes...

2026-02-11 | MTBLS13253 | MetaboLights
MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
MetabolomicsCharacterization of small intracellular vesicles uncovers their potential as drug carriers and therapeutic agents

Small extracellular vesicles (sEVs) have been extensively investigated as a source of clinically relevant cargo. Alongside the secretion of EVs, such as exosomes, cells house a multitude of internal vesicles involved in various physiologic processes and metabolic activities. Herein, we developed ...

2025-09-02 | MTBLS12923 | MetaboLights
ProteomicsThe proteome of Fibrobacter succinogenes S85 outer membrane vesicles
Here, we illustrate the proteomic composition and hydrolytic capacity of outer membrane vesicles (OMVs) produced by F. succinogenes during growth on Avicel cellulose and show that the OMVs are equipped with a highly versatile polysaccharide-degrading machinery. Proteomic assessment identified an enr...
ORGANISM(S): Fibrobacter succinogenes subsp. succinogenes S85 
2017-06-30 | PXD005442 | Pride
Outer membrane vesicles Omv Hydrolytic enzymes 
ProteomicsLocalisation of outer membrane proteins in Treponema denticola by quantitative proteome analyses of outer membrane vesicles and cellular fractions
The identification and localisation of outer membrane proteins (Omps) and lipoproteins in pathogenic treponemes such as T. denticola (periodontitis) and T. pallidum (syphilis) has been challenging largely due to the structural uniqueness of their outer membranes (OM), the high abundance of inner mem...
ORGANISM(S): Treponema denticola ATCC 35405 
2019-02-20 | PXD011495 | Pride
Treponema denticola Localization Outer membrane vesicles Bacterial lipoproteins Maxquant Outer membrane proteins Orbitrap 
TranscriptomicsOsteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells
Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including...
ORGANISM(S): Homo sapiens 
2016-10-05 | E-MTAB-4560 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of the Neisseria gonorrhoeae cell envelope and membrane vesicles
Neisseria gonorrhoeae (GC) is a human-specific pathogen, and the agent of a sexually transmitted disease, gonorrhea. There is a critical need for new approaches to study and treat GC infections because of the growing threat of multidrug-resistant isolates and the lack of a vaccine. Despite the impli...
ORGANISM(S): Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) 
2014-12-19 | PXD000549 | Pride
Itraq Neisseria gonorrhoeae Cell envelope Native membrane vesicles Drug and vaccine targets 
UnknownProtein-enriched outer membrane vesicles as a native platform for outer membrane protein studies.
Not available
S-EPMC6123736 | biostudies-literature
UnknownImproving cell-free glycoprotein synthesis by characterizing and enriching native membrane vesicles.
Not available
S-EPMC8062659 | biostudies-literature
ProteomicsProteomics of Extracellular Vesicles Harvested with ExtraPEG
Polyethylene glycol (PEG) is commonly used to isolate virus particles from culture medium. This project adapted and optimized the virus procedure for harvesting extracellular vesicles (of similar biophysical properties to viruses) from media. An 8% PEG solution harvested the purest vesicles. Followe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079996 | MassIVE
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