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MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
TranscriptomicsNatural Killer Cells from High Grade Serous Ovarian Carcinoma ascites
Natural killer cells were extracted from the peritoneal cells of ascites of high grade serous ovarian carcinoma patients.
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-14053 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neonatal and adult mouse natural killer cells
Comparing global gene expression of neonatal and adult natural killer cells to determine if differences in gene expression suggest that different developmental pathways during hematopoiesis are followed in the fetal and adult mouse to produce mature natural killer cells.
ORGANISM(S): Mus musculus 
2005-10-01 | E-MEXP-354 | biostudies-arrayexpress
TranscriptomicsNatural Killer cells treated with arachidonic acid, IL-2 and ascites
Natural killer cells were exptracted from PMBCs of healthy donors, exposed to arachidonic acid, Il-2, both, or ascites and their expression changes identified via RNAseq (QuantSeq).
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-13971 | biostudies-arrayexpress
TranscriptomicsExperimental Malaria Infection Triggers Early Expansion of Natural Killer Cells
In order to gain a better understanding of gene expression during early malaria infection, we conducted microarray analysis of early blood responses in mice infected with erythrocytic stage Plasmodium chabaudi. Immediately following infection, we observed coordinated and sequential waves of immune ...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-12249 | biostudies-arrayexpress
TranscriptomicsExperimental Malaria Infection Triggers Early Expansion of Natural Killer Cells - NK cell response
In order to gain a better understanding of gene expression during early malaria infection, we conducted microarray analysis of early blood responses in mice infected with erythrocytic stage Plasmodium chabaudi. Immediately following infection, we observed coordinated and sequential waves of immune ...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-12727 | biostudies-arrayexpress
Proteomicsthe MS data involved in the article "Nuclear ACAT1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer"
In this study we aim to explore the metabolic enzyme that affects NK cell function in colorectal cancer, and mainly focus on the mechanism how nuclear ACAT1（Mitochondrial acetyl-CoA acetyltransferase）promotes NK cell infiltration and activation
ORGANISM(S): Homo Sapiens 
2025-03-18 | PXD061959 |
MetabolomicsFunctional Remodeling of iNKT Cells by Sulfatide-Reactive Type II NKT Cells Reprograms Alveolar Macrophages to Alleviate Lung Ischemia-Reperfusion Injury

Lung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear. In this study, we establish a LIRI mouse model and demonstrate that sulfatide-reactive type...

2025-12-19 | MTBLS13533 | MetaboLights
TranscriptomicsTOX2 regulates human natural killer cell development by controlling T-BET expression
Thymocyte selection-associated high mobility group box protein family member 2 (TOX2) is a transcription factor belonging to the TOX family that shares a highly conserved high mobility group DNA binding domain with the other TOX members. While TOX1 has been shown to be an essential regulator of T-ce...
ORGANISM(S): Homo sapiens 
2014-12-22 | E-GEOD-58589 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing and single-cell CRISPR screens of interacting natural killer and blood cancer cells
To profile the cell states of interacting natural killer (NK) cells and blood cancer cells, we cultured 26 different cell lines representing diverse hematologic neoplasms either alone or with NK cells derived from three healthy human donors. After 24 h co-culture, we labeled the cells from each mono...
ORGANISM(S): Homo sapiens 
2023-07-24 | E-MTAB-13204 | biostudies-arrayexpress
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