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ProteomicsIdentification of HIV Tat and NF-kB binding proteins associated with semen derived extracellular vesicles. In this study, we used orthogonal pull-downs, mobility shift, and electrophoretic protein binding assays coupled with proteomic and secretomic analyses to highlights the previously unappreciated SEV-associated transcriptional repressors that may target HIV Tat to suppress viral transcription.
Semen-derived extracellular vesicles (SEVs) have been shown to inhibit the human immunodeficiency virus type 1 (HIV-1) LTR transactivation through the blockade of the interaction of transactivator of transcription (Tat) and host transcription factors NF-kB and Sp1 (Tat•NF-ᴋB p65 and Tat•Sp1). The ab...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD062816 | Pride
Hiv Extracellular vesicles Tat Nfkb 
ProteomicsIdentification of HIV Tat and NF-kB binding proteins associated with semen derived extracellular vesicles In this study, we used orthogonal pull-downs, mobility shift, and electrophoretic protein binding assays coupled with proteomic and secretomic analyses to highlights the previously unappreciated SEV-associated transcriptional repressors that may target HIV Tat to suppress viral transcription.
Semen-derived extracellular vesicles (SEVs) have been shown to inhibit the human immunodeficiency virus type 1 (HIV-1) LTR transactivation through the blockade of the interaction of transactivator of transcription (Tat) and host transcription factors NF-kB and Sp1 (Tat•NF-ᴋB p65 and Tat•Sp1). The ab...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD062784 | Pride
Hiv Extracellular vesicles Tat Nfkb 
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