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TranscriptomicsTreatment effects of trastuzumab and TDM-1 in a murine model of breast cancer brain metastasis
Background: Central nervous system (CNS) metastases represent a major problem in the treatment of HER2-positive breast cancer due to the disappointing efficacy of HER2-targeted therapies in the brain microenvironment. The antibody-drug conjugate ado-trastuzumab emtansine (T-DM1) has shown efficacy i...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-69042 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers at different time points after partial hepatectomy and at different time points post conception to elucidate gene expression similarities between regenerating and developing liver.
Normal adult liver is uniquely capable of renewal; and repair after injury. Whether this response; represents simple hyperplasia of various liver elements; or requires recapitulation of the genetic program of; the developing liver is not known. To study these possibilities, we examined transcription...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6998 | biostudies-arrayexpress
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