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ProteomicsNoncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing globally in recent years. The development of immunotherapies for colon cancer is critical for providing new treatment strategies to combat drug resistanc...
ORGANISM(S): Escherichia coli 
2026-01-12 | PXD069482 | Pride
Bispecific antibody Maldi-tof Noncanonical amino acid 
UnknownDeciphering the conformational landscape of few selected aromatic noncoded amino acids (NCAAs) for applications in rational design of peptide therapeutics.
Not available
S-EPMC9207436 | biostudies-literature
TranscriptomicsRare codon recoding for selective and efficient noncanonical amino acid incorporation [RNA-seq]
The ability to genetically encode noncanonical amino acids (ncAAs) has empowered proteins with improved or novel properties. However, existing strategies in mammalian cells rely on the introduction of blank codon for incorporating ncAAs, which is very inefficient and limits their widespread applicat...
ORGANISM(S): Homo sapiens 
2025-01-01 | GSE255464 | GEO
OtherRare codon recoding for selective and efficient noncanonical amino acid incorporation [Ribo-seq]
The ability to genetically encode noncanonical amino acids (ncAAs) has empowered proteins with improved or novel properties. However, existing strategies in mammalian cells rely on the introduction of blank codon for incorporating ncAAs, which is very inefficient and limits their widespread applicat...
ORGANISM(S): Homo sapiens 
2025-01-01 | GSE255465 | GEO
ProteomicsRecoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids
Expanding the genetic code has revolutionized our ability to study and manipulate biological systems through site-specific incorporation of noncanonical amino acids (ncAAs). However, current methods are primarily limited to single-type ncAA incorporation in mammalian cells owing to translation ineff...
ORGANISM(S): Homo Sapiens 
2025-11-04 | PXD070277 |
UnknownDirected evolution of the fluorescent protein CGP with in situ biosynthesized noncanonical amino acids.
Not available
S-EPMC11022568 | biostudies-literature
UnknownA robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli.
Not available
S-EPMC12480666 | biostudies-literature
UnknownGenetically encoded crosslinkers to address protein-protein interactions.
Not available
S-EPMC10117390 | biostudies-literature
UnknownEngineering enzymes for noncanonical amino acid synthesis.
Not available
S-EPMC6434697 | biostudies-literature
UnknownDesign and evolution of artificial enzyme with in-situ biosynthesized non-canonical amino acid.
Not available
S-EPMC12485135 | biostudies-literature
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