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TranscriptomicsGene expression profiling in NCoR deficient mouse livers
The thyroid hormone receptor (TR) has been proposed to regulate target genes in the absence of triiodothyronine (T3), through the recruitment of the corepressors, NCoR and SMRT. NCoR and SMRT may thus play a key role in both hypothyroidism and resistance to thyroid hormone, though this has never bee...
ORGANISM(S): Mus musculus 
2008-12-03 | E-GEOD-10001 | biostudies-arrayexpress
TranscriptomicsA Bcl6-Smrt/Ncor repression program controls atherosclerosis
This SuperSeries is composed of the following subset Series: GSE27001: Inhibition of Bcl6-SMRT/NCoR interactions by an inhibitory peptide affects inflammatory pathways GSE27033: Genome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-27060 | biostudies-arrayexpress
ProteomicsStructural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ
Heme is the endogenous ligand for the constitutively repressive REV-ERB nuclear receptors, REV-ERBα (NR1D1) and REV-ERBβ (NR1D2), but how heme regulates REV-ERB activity remains unclear. While cellular studies indicate heme is required for the REV-ERBs to bind the corepressor NCoR and repress transc...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-24 | PXD021761 | Pride
Orphan nuclear receptor Rev-erb Ligand binding Protein-protein interactions 
GenomicsGenome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages
Using ChIP-seq, we reveal the SMRT and NCoR co-repressor cistromes, which each consist of over 30,000 half-shared binding sites. Moreover, we identify Bcl6-bound sub-cistromes for each co-repressor, which are strongly concentrated on NF-κB-driven inflammatory and tissue remodeling genes. These res...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-27033 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophage responses to all-trans retinoic acid between wild type and NCoR-/- mice
Comparison of mouse macrophage responses to all-trans retinoic acid between wild-type and NCoR-/- mice.
ORGANISM(S): Mus musculus 
2006-11-06 | E-MEXP-37 | biostudies-arrayexpress
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophage responses to lipopolysaccharide (LPS) and 12-o-tetradecanoylphorbol-13-acetate (TPA) in wild type and NcoR-/- mice
Comparison of mouse macrophage responses to lipopolysaccharide (LPS) and 12-o-tetradecanoylphorbol-13-acetate (TPA) between wild-type and NcoR-/- mice.
ORGANISM(S): Mus musculus 
2006-11-06 | E-MEXP-38 | biostudies-arrayexpress
TranscriptomicsInhibition of Bcl6-SMRT/NCoR interactions by an inhibitory peptide affects inflammatory pathways
Using microarrays, we compared the changes in levels of gene expression between wild type mouse bone marrow derived macrophages upon treatment with the Bcl6 peptide inhibitor, RI-BPI, that specifically blocks interaction between BCL6 and the co-repressors NCoR or SMRT. Total RNA was obtained from cu...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-27001 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophage responses to 12-o-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide (LPS), and LPS plus dexamethasone between wild type and NCoR-/- mice
Comparison of mouse macrophage responses to 12-o-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide (LPS), and LPS plus dexamethasone between wild-type and NCoR-/- mice.
ORGANISM(S): Mus musculus 
2004-08-01 | E-MEXP-39 | biostudies-arrayexpress
TranscriptomicsGEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates development and neuronal functions in C. elegans.
NCoR and SMRT are two paralogous vertebrate proteins that function as corepressors with unliganded nuclear receptors. Although C. elegans has a large number of nuclear receptors, orthologues of the corepressors NCoR and SMRT have not unambiguously been identified in Drosophila or C. elegans. Here,...
ORGANISM(S): Caenorhabditis elegans 
2013-08-11 | E-GEOD-40127 | biostudies-arrayexpress
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