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MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
GenomicsP-TEFb function in ncRNA transcription
P-TEFb function in ncRNA transcription
PRJNA483416 | ENA
ProteomicsDiscovery of RUF6 ncRNA interacting proteins involved in P. falciparum immune evasion
RUF6 is a ncRNA gene family that is transcribed by RNA Polymerase III but actively regulates the Pol II-transcribed var virulence gene family. Understanding how RUF6 ncRNA connect to downstream effectors is lacking. We developed an RNA-directed proteomic discovery (ChIRP-MS) protocol to identify in ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-11-15 | PXD036801 | Pride
Var genes Malaria virulence Ruf6 ncrna Plasmodium falciparum Antigenic variation 
TranscriptomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [RNA-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54240 | biostudies-arrayexpress
GenomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54239 | biostudies-arrayexpress
UnknownSingle-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA Transcription.
Not available
S-EPMC4656089 | biostudies-literature
GenomicsP-TEFb function in ncRNA transcription
Many ncRNAs serve as regulatory molecules in various physiological pathways. Distinct from protein-coding RNA expression, ncRNA expression is regulated solely by transcription and RNA processing/stability. Transcriptional regulation in ncRNA genes is thus important to be understood and is yet to be ...
ORGANISM(S): Homo sapiens 
2018-07-31 | GSE117848 | GEO
ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Transcriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass...
ORGANISM(S): Homo Sapiens 
2023-10-16 | PXD038532 | panorama
GenomicsRNA-Chromatin Interactome Reveals ncRNA Functions for Transcription Regulation in 3D Genome Organization
RNA-Chromatin Interactome Reveals ncRNA Functions for Transcription Regulation in 3D Genome Organization
PRJNA339288 | ENA
UnknownMetabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene.
Not available
S-EPMC10802949 | biostudies-literature
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