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ProteomicsNdfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
Project abstract: Foxp3+ T regulatory (Treg) cells have important functions in suppressing immune cell activation and establishing normal immune homeostasis. How Treg cells maintain their identity is not completely understood. Here we show that Ndfip1, a co-activator of Nedd4-family E3 ubiquitin lig...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-19 | PXD006251 | Pride
Effector-type regulatory t cells (etreg cells) Ndfip1 Central regulatory t cells (ctreg cells) Regulatory t cells (treg cells) 
UnknownNDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation.
Not available
S-EPMC10019574 | biostudies-literature
UnknownNdfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells.
Not available
S-EPMC7813998 | biostudies-literature
UnknownDivalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
Not available
S-EPMC2741278 | biostudies-literature
UnknownNdfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease.
Not available
S-EPMC5465375 | biostudies-literature
UnknownDifferentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity.
Not available
S-EPMC11732889 | biostudies-literature
UnknownNdfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production.
Not available
S-EPMC5209687 | biostudies-literature
UnknownThe ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility.
Not available
S-EPMC3905456 | biostudies-literature
UnknownGenetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients.
Not available
S-EPMC8560952 | biostudies-literature
UnknownCabergoline-induced NDFIP1 upregulation in pituitary neuroendocrine tumor cells activates mTOR signaling and contributes to cabergoline resistance.
Not available
S-EPMC11968467 | biostudies-literature
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