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TranscriptomicsMolecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis
N-nitroso compounds (NOC) are genotoxic compounds and animal carcinogens, and may play a role in human cancer development. Since the gastro-intestinal tract is an important route of exposure, we hypothesize that NOC exposure targets genetic processes relevant in colon carcinogenesis. To investigate ...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14284 | biostudies-arrayexpress
GenomicsSpatial transcriptomics profiling of NDMA-induced liver injury in Mgmt-deficient mice across sex and time
Spatial transcriptomics profiling of NDMA-induced liver injury in Mgmt-deficient mice across sex and time
PRJNA1468680 | ENA
UnknownOxidation of Citalopram with Sodium Hypochlorite and Chlorine Dioxide: Influencing Factors and NDMA Formation Kinetics.
Not available
S-EPMC6749231 | biostudies-literature
UnknownIn Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions.
Not available
S-EPMC8239951 | biostudies-literature
TranscriptomicsSpatial transcriptomics profiling of NDMA-induced liver injury in Mgmt-deficient mice across sex and time
Spatial transcriptomics (10x Genomics Visium) was performed on fresh-frozen liver tissue (left lobe) from Mgmt-/- mice treated with N-nitrosodimethylamine (NDMA) or saline vehicle during the juvenile period. The study includes male and female mice sacrificed at 10 weeks or 10 months post-birth to ch...
ORGANISM(S): Mus musculus 
2026-05-22 | GSE332601 | GEO
UnknownEffect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Randomized Clinical Trial.
Not available
S-EPMC8240005 | biostudies-literature
UnknownUse of N-nitrosodimethylamine (NDMA) contaminated valsartan products and risk of cancer: Danish nationwide cohort study.
Not available
S-EPMC6134800 | biostudies-literature
TranscriptomicsSilica-mediated airway chronic inflammation promotes lung carcinogenesis through the activation of preneoplastic lesions in the context of an immunosuppressive microenvirontment
Basic studies on preneoplastic lesions are important to determine the molecular alterations that take place in early steps of lung carcinogenesis. Little is known about the molecular events preceding the development of lung cancer in the context of an inflammatory environment. In this study we repor...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-43453 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints
Transcriptomic profiling of mouse liver tissue to characterize the acute and long-term gene expression response to the carcinogen N-nitrosodimethylamine (NDMA) in juvenile mice. RaDR+/+;GPT+/+ (WT) and RaDR+/+;GPT+/+;Mgmt-/- (Mgmt knockout) mice received intraperitoneal injections of NDMA (3.5 mg/kg...
ORGANISM(S): Mus musculus 
2026-05-22 | GSE332646 | GEO
GenomicsBulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints
Bulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints
PRJNA1468715 | ENA
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