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ProteomicsHuman NDMM MHC-I immunopeptidome mass spectrometry
To assess the contribution of ribosome profiling-detected nuORFs in NDMM to the MHC-I immunopeptidome and their potential for generating neoantigens, we obtained MHC-I immunopeptidome mass spectrometry (MS/MS) spectra from three patients with NDMM.
ORGANISM(S): Homo sapiens (Human) 
2025-02-20 | PXD047053 | Pride
Human Ndmm Mhc-i Lc-ms/ms 
ProteomicsProteomics-based approach reveals the involvement of SERPINB9 in recurrent and relapsed multiple myeloma
Multiple myeloma (MM) is a common hematological malignancy with poorly understood recurrence and relapse mechanisms. Notably, bortezomib resistance leading to relapse makes MM treatment significantly challenging. To clarify the drug resistance mechanism, we employed a quantitative proteomics approac...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD022182 | Pride
Multiple myeloma  recurrence and relapse  proteomics  parallel reaction monitoring  serpinb9 
UnknownThe location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM.
Not available
S-EPMC10163314 | biostudies-literature
UnknownFrail subgroups determine heterogeneous outcomes in older patients with NDMM: long-term follow-up of the HOVON 143 trial.
Not available
S-EPMC12663016 | biostudies-literature
TranscriptomicsRevealing differential type I and type II IFN responses in different immune cells in various human diseases by a new IFNs transcriptomic atlas
Interferons (IFNs) are key cytokines mediating broad immunological responses in diverse processes including host defense, autoimmune diseases, and cancer. To gain single cell resolution in response to different IFNs in different human immune cells, we generated a new single-cell transcriptomic datas...
ORGANISM(S): Homo sapiens 
2026-06-30 | GSE306664 | GEO
TranscriptomicsMemory-like natural killer cells facilitate effector functions of daratumumab in multiple myeloma
Natural killer (NK) cells support the anti-myeloma activity of daratumumab via antibody-dependent cellular cytotoxicity (ADCC) in multiple myeloma (MM). However, the different roles of heterogeneous NK cell subpopulations have not been elucidated in MM. Here, we delineate memory-like NK cells in the...
ORGANISM(S): Homo sapiens 
2021-08-01 | GSE155795 | GEO
TranscriptomicsNewly diagnosed multiple myeloma patients with poor response to standard therapy
In this study, we analyzed transcriptome sequencing data to compare NDMM patients who were poor responders to the standard treatment approach (progression free survival < 24 months) to patients who were standard responders (progression free survival > 24 months).
ORGANISM(S): Homo sapiens 
2024-07-17 | GSE267013 | GEO
TranscriptomicsGlobal transcriptome analysis of early and terminal erythropoiesis in newly diagnosed with multiple myeloma patients associated anemia
In NDMM anemia patients, erythroid progenitors show downregulation of growth factor response pathways (e.g., SPHK1), while terminal erythroblasts have upregulation of mitochondrial oxidative phosphorylation and p53-related genes, with increased cellular ROS levels. Mechanistically, genes like COX6C,...
ORGANISM(S): Homo sapiens 
2025-09-18 | GSE301441 | GEO
UnknownTertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas.
Not available
S-EPMC9828737 | biostudies-literature
UnknownPrognosis of hepatitis B virus reactivation in newly diagnosed multiple myeloma in modern era therapy: a retrospective study.
Not available
S-EPMC11533906 | biostudies-literature
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