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ProteomicsDNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of Lamin A/C - Synthetic Peptide
The integrity of the nuclear envelope (NE) is essential to maintain the structural stability of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in the context of mechanical challenges, such as physical confinement and migration. However, spontaneous NE rupture...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD043990 | Pride
Atr Ne vulnerability Nuclear envelope rupture Hr-deficiency Lamina Lamin a/c phosphorylation Dna damage Synthetic lethality 
ProteomicsDNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of Lamin A/C
The integrity of the nuclear envelope (NE) is essential to maintain the structural stability of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in the context of mechanical challenges, such as physical confinement and migration. However, spontaneous NE rupture...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD040857 | Pride
Atr Ne vulnerability Nuclear envelope rupture Hr-deficiency Lamina Lamin a/c phosphorylation Dna damage Synthetic lethality Targeted therapy Replication stress 
UnknownMapping Heat Vulnerability Index Based on Different Urbanization Levels in Nebraska, USA.
Not available
S-EPMC8533801 | biostudies-literature
UnknownSocial vulnerability, social-ecological resilience and coastal governance.
Not available
S-EPMC10304588 | biostudies-literature
UnknownSK4 calcium-activated potassium channels activated by sympathetic nerves enhances atrial fibrillation vulnerability in a canine model of acute stroke.
Not available
S-EPMC7215192 | biostudies-literature
TranscriptomicsCombined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Broad Spectrum of Cancer Therapeutics and Confers Vulnerability to Replication Stress
Prostate cancers (PC) with loss of the potent tumor suppressors TP53 and RB1 exhibit poor outcomes that include resistance to androgen receptor (AR) pathway antagonists. TP53 and RB1 also influence cell plasticity and are frequently lost in PCs with neuroendocrine (NE) differentiation. Therapeutic s...
ORGANISM(S): Homo sapiens 
2020-06-01 | GSE147250 | GEO
UnknownSocio-ecological impact of monogenetic volcanism in the La Garrotxa Volcanic Field (NE Iberia).
Not available
S-EPMC10199944 | biostudies-literature
UnknownActin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer.
Not available
S-EPMC12795832 | biostudies-literature
UnknownDemographic Characteristics and County-level Indicators of Social Vulnerability in Salmonellosis Outbreaks Linked to Ground Beef-United States, 2012-2018.
Not available
S-EPMC11773426 | biostudies-literature
UnknownEpigenetic Mechanism of 5-HT/NE/DA Triple Reuptake Inhibitor on Adult Depression Susceptibility in Early Stress Mice.
Not available
S-EPMC8968447 | biostudies-literature
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