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GenomicsGlobal Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II
We developed a novel approach to isolate and characterize, at nucleotide-level resolution, the RNAs derived from RNA polymerase II (Pol II) in early elongation complexes. We find that high numbers of these short RNAs are not correlated with gene expression but instead are indicative of promoter-prox...
ORGANISM(S): Drosophila melanogaster 
2009-12-11 | E-GEOD-18643 | biostudies-arrayexpress
TranscriptomicsRNA polymerase is poised for activation across the genome
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA ...
ORGANISM(S): Drosophila melanogaster 
2007-11-11 | E-GEOD-6714 | biostudies-arrayexpress
TranscriptomicsUpstream Anti-sense Promoters Act as Local Enhancers of Mammalian Protein-coding Genes
Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is known about the function or regulation of these anti-sense promoters or the non-coding RNAs they generate. Here we define at nucleotide resolution the divergent t...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-62151 | biostudies-arrayexpress
TranscriptomicsStable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals
Metazoan gene expression is often regulated after the recruitment of RNA polymerase II (Pol II) to promoters, through the controlled release of promoter-proximally paused Pol II into productive RNA synthesis. Despite the prevalence of paused Pol II, very little is known about the dynamics of these e...
ORGANISM(S): Drosophila melanogaster 
2013-10-31 | E-GEOD-49078 | biostudies-arrayexpress
GenomicsRNA Polymerase II Pausing Can Be Retained or Acquired During Activation of Genes Involved in the Epithelial to Mesenchymal Transition
Promoter-proximal RNA polymerase II (Pol II) pausing is implicated in the regulation of gene transcription. However, the mechanisms of pausing including its dynamics during transcriptional responses remain to be fully understood. We performed global analysis of short capped RNAs and Pol II Chromatin...
ORGANISM(S): Homo sapiens 
2015-03-27 | E-GEOD-67041 | biostudies-arrayexpress
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