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MetabolomicsFrom Microbiota to Metabolomics: How Bifidobacterium infantis YLGB-1496 Shields Neonates from Necrotizing enterocolitis

Bifidobacterium species are recognized as essential primary colonizers of the infant gastrointestinal tract and constitute a critical component of infant formula. Nevertheless, the precise mechanisms by which Bifidobacterium confers its protective effects against gut inflammation remain insuffici...

2025-10-20 | MTBLS13018 | MetaboLights
MetabolomicsBlocking NKp46-CCR6-ILC3 autophagy alleviates necrotizing enterocolitis by restoring energy metabolism balance

Group 3 innate lymphoid cells (ILC3s) play a crucial role in intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) in neonates; however, the mechanisms by which ILC3s contribute to NEC remain unclear. In this study, single-cell transcriptomics, in vivo experiments on T cell-de...

2026-04-12 | MTBLS12891 | MetaboLights
ProteomicsNecrotizing enterocolitis rat_DFAT cell treatment_ileum
Quantification of proteins in the ileum of Necrotizing enterocolitis.
ORGANISM(S): Rattus Rattus (black Rat) 
2022-04-27 | PXD025647 | JPOST Repository
TranscriptomicsAmniotic fluid and necrotizing enterocolitis in preterm pigs
Preterm neonates are susceptible to gastrointestinal (GI) disorders such as necrotizing enterocolitis (NEC). Maternal milk, and especially colostrum, protects against NEC via growth promoting, immunomodulatory and antimicrobial factors. The fetal enteral diet, amniotic fluid (AF), contains similar b...
ORGANISM(S): Sus scrofa 
2010-05-06 | E-GEOD-13515 | biostudies-arrayexpress
TranscriptomicsNeonatal antibotic prophylaxis modulates intestinal immunity and prevents necrotizing enterocolitis in preterm neonates
Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula feeding. Antibiotics (n=11) or control saline (n=13) were given twice daily from birth to tissue collection at d 5. NEC-lesions and intestinal structure, function, microbiology and immunity marke...
ORGANISM(S): Sus scrofa 
2013-08-21 | E-GEOD-48125 | biostudies-arrayexpress
TranscriptomicsTemporal development of necrotizing enterocolitis in the preterm pig
Necrotizing enterocolitis (NEC), a serious gastrointestinal disease that afflicts 5-10% of preterm infants, often progresses rapidly from mild food intolerance into extensive haemorrhage, inflammation and necrosis. Events leading to NEC have remained poorly defined. Similar disease characteristics a...
ORGANISM(S): Sus scrofa 
2010-05-07 | E-GEOD-13516 | biostudies-arrayexpress
TranscriptomicsBowel miRNA expression profiles of infants with gastrointestinal conditions
We have employed miRNA microarray expression profiling to identify miRNA differentially expressed in neonatal bowel tissues with different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotizing enterocolitis (NEC), spontaneous intestina...
ORGANISM(S): Homo sapiens 
2015-08-24 | E-GEOD-68054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the effects of hypoxia, breast and formula feeding on a Rattus norvegicus model of necrotizing enterocolitis
Necrotizing Enterocolitis (NEC) is an inflammation causing injury to the bowel in newborns. This project uses a rodent model that mimics the intestinal pathological changes seen in NEC to study the effect of formula feeding and hypoxia on NEC development
ORGANISM(S): Rattus norvegicus 
2007-10-11 | E-GEOD-491 | biostudies-arrayexpress
TranscriptomicsBowel expression profiles of infants with gastrointestinal conditions
We have employed whole genome microarray expression profiling to identify genes differentially expressed in neonatal bowel tissues of different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotising enterocolitis (NEC) and spontaneous i...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-46619 | biostudies-arrayexpress
ProteomicsData in support of Circulating neutrophil extracellular trap components including cell-free DNA are associated with neonatal sepsis and necrotizing enterocolitis in newborn, immature infants, pigs and mice
Preterm infants are highly susceptible to late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) but specific biomarkers for diagnosis and effective treatment are lacking. Neutrophil extracellular traps (NETs) are related to sepsis in adults but not investigated in infant conditions. This is th...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-03-05 | PXD004082 | Pride
Necrotizing enterocolitis Preterm neonates Sepsis Neutrophil extracellular traps 
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