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TranscriptomicsTumor suppressor role of Ezh2 in an NRASQ61K driven model of Early T-cell Precursor Acute Lymphoblastic Leukemia (RNA-Seq)
Purpose: To characterize transcriptional changes associated with homozygous inactivation the Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase Ezh2 in a mouse model of earlt T-cell precursor ALL (ETP-ALL) Methods: We sequenced mRNA from NRASQ61K transformed murine LSK-cells co-transduced...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-76602 | biostudies-arrayexpress
GenomicsTumor suppressor role of Ezh2 in an NRASQ61K driven model of Early T-cell Precursor Acute Lymphoblastic Leukemia (ChIP-Seq)
Purpose: To characterize changes in genome-wide H3K27me3 associated with homozygous inactivation the Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase Ezh2 in a mouse model of earlt T-cell precursor ALL (ETP-ALL) Methods: We performed Chip-seq for the H3K27me3 Chromatin mark on Ezh2ff an...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-76601 | biostudies-arrayexpress
TranscriptomicsTumor suppressor role of Ezh2 in an NRASQ61K driven model of Early T-cell Precursor Acute Lymphoblastic Leukemia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-76603 | biostudies-arrayexpress
TranscriptomicsExpression profiling of primary wild type (WT), Ezh2-null and Eed-null murine MLL-AF9 AML
We evaluated gene expression changes in murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of homozygous conditional alleles for Ezh2 or Eed, both of which are components of the Polycomb...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34959 | biostudies-arrayexpress
TranscriptomicsExpression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML
We evaluated gene expression changes in secondary recipient murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of a homozygous conditional allele for Ezh2, a component of the Polycomb Re...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34961 | biostudies-arrayexpress
TranscriptomicsThe Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-76750 | biostudies-arrayexpress
GenomicsThe Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML [Mouse ChIP-seq]
Purpose: To characterize the genome-wide distribution of H3K79me2 in murine MN1 driven myeloid leukemia Methods: We performed Chip-seq for the H3K79me2 in leukemias isolated from moribund mice that had been injected with common myeloid progenitors (CMPs) transduced with MSCV-MN1-GFP Results: H3K79me...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-76746 | biostudies-arrayexpress
TranscriptomicsThe Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML [Mouse Dot1l ko RNA-seq]
Purpose: To characterize transcriptional changes associated with homozygous inactivation of Dot1l or Mll1 in MN1 driven AML Methods: We sequenced mRNA from murine LSK-cells transformed using forced expression of MN1 (MSCV-MN1-IRES-GFP), and transduced with Cre-vector to inactivate either Dot1l or Ml...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-76748 | biostudies-arrayexpress
TranscriptomicsThe Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML [Mouse Mll1 ko RNA-seq]
Purpose: To characterize transcriptional changes associated with homozygous inactivation of Dot1l or Mll1 in MN1 driven AML Methods: We sequenced mRNA from murine LSK-cells transformed using forced expression of MN1 (MSCV-MN1-IRES-GFP), and transduced with Cre-vector to inactivate either Dot1l or Ml...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-76749 | biostudies-arrayexpress
TranscriptomicsThe Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML [Human RNA-seq]
Purpose: To characterize transcriptional changes associated with inhibition of Dot1l in 2 inv(16) patient AML samples Methods: We sequenced mRNA from patient samples that were exposed to 5 uM EPZ004777 or DMSO control for 7 days. Results: Inhibition of Dot1l leads to gene expression changes in gene...
ORGANISM(S): Homo sapiens 
2016-01-12 | E-GEOD-76747 | biostudies-arrayexpress
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