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GenomicsMutational patterns and regulatory networks in epigenetic subgroups of meningioma (H033)
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign-1, 2, 3, intermediate-A, B and malignant. Here, we set out to identify subgroup-specific mutational patterns and pathway regulation. Whole-gen...
EGAS00001003481 | EGA
Genomicsbe40ebac-acee-4026-a661-4330bb0f657b - samples
Bam files for 124 samples (62 tumor vs blood pairs); Whole Genome Sequencing performed on Illumina HiSeq X Ten
EGAD00001005061 | EGA
Genomicsbc246e56-19ea-4c30-9e33-160ac12c3050 - samples
Bam files for 16 meningioma tumor samples; ChIPseq performed on Illumina HiSeq 2000
EGAD00001005021 | EGA
GenomicsData Access Committee of divisions B060 and B062, German Cancer Research Center (DKFZ)
Data Access Committee EGAC00001000219
EGAC00001000219 | EGA
ProteomicsMapping naturally presented T-cell antigens in medulloblastoma based on integrative multi-omics
Medulloblastoma is the most frequent malignant primary brain tumor in children. Despite recent advances in integrated genomics, the prognosis in children with high-risk medulloblastoma remains devastating, and new tumor-specific therapeutic approaches are needed. Here, we present an atlas of natural...
ORGANISM(S): Homo sapiens (Human) 
2024-08-24 | PXD043770 | Pride
Medulloblastoma Immunopeptidomics Rna-seq 
ProteomicsHigh-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Glioblastoma, the most aggressive primary brain cancer, has dismal prognosis, yet systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies may emerge from exploring neurodevelopmental and neurophysiological vulnerabilities of glioblastoma. To this end, we here syste...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090357 | MassIVE
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