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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
ProteomicsBlocking muscle wasting via deletion of the muscle specific E3 ligase MuRF1 impedes pancreatic tumor growth – ubiquitome dataset
Cancer-induced muscle wasting reduces quality of life, complicates or precludes cancer treatments, and predicts early mortality. Herein, we investigated the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting induced by pancreatic cancer. Murine pancreatic cancer (KPC) ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-15 | PXD039151 | Pride
Proteasome system Cancer cachexia Mus musculus Murf1 Muscle wasting Pancreatic cancer 
GenomicsSetdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
Purpose: The aim of this study is (1) to identify the chromatin occupancy of the epigenetic regulator Setdb1 in mouse embryonic fibroblasts (MEF); (2) to profile key epigenetic marks H3K9me2, H3K9me3 and H3K27me3; utilizing wildtype cells with nonsilencing shRNA mediated knockdown and Setdb1 geneTra...
ORGANISM(S): Mus musculus 
2016-05-18 | E-GEOD-66522 | biostudies-arrayexpress
UnknownAre individual differences in appetitive and defensive motivation related? A psychophysiological examination in two samples.
Not available
S-EPMC3962705 | biostudies-literature
UnknownPAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans.
Not available
S-EPMC4469536 | biostudies-literature
GenomicsA Genome-Wide Association Study of Heroin Dependence

This collaboration of Australian and American investigators aims to identify genes associated with liability for heroin dependence. The project uses a case-control design in which cases met lifetime DSM-IV criteria for heroin dependence. Controls included assessed individuals who did not meet DSM...

phs000277.v1.p1 | EGA
UnknownMethods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives.
Not available
S-EPMC1399450 | biostudies-literature
TranscriptomicsCryptic Transcription in a set2∆ in Saccharomyces cerevisiae
In cells lacking the histone methyltransferase Set2, initiation of RNA polymerase II transcription occurs inappropriately within the protein-coding regions of genes, rather than being restricted to the proximal promoter. Here, we mapped the transcripts produced in an S. cerevisiae strain lacking Set...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-17 | E-GEOD-13310 | biostudies-arrayexpress
UnknownPreparation of cellulose nanocrystal (CNCs) reinforced polylactic acid (PLA) bionanocomposites filaments using biobased additives for 3D printing applications.
Not available
S-EPMC10448353 | biostudies-literature
TranscriptomicsSingle-cell RNA-seq transcriptome profiling of Prdm1+ lineages in E9.5 mouse placenta
Our goal was to transcriptionally profile Prdm1+ cell lineages of maternal and embryonic origin in mid-gestation mouse placenta in order to study vascular mimicry and additional processes in the placenta. Profiling of 61 single cells and 17 clusters of 2 or 3 cells chosen based on expression of Prdm...
ORGANISM(S): Mus musculus 
2016-03-14 | E-GEOD-74406 | biostudies-arrayexpress
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