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TranscriptomicsTranscription profiling of 5 mouse strains liver, kidney and testis to identify the contribution of normal variation and genetic background to mammalian gene expression
5 mouse strains, 3 mice per strain, and 4 microarrays per mouse for a total of 60 microarray experiments. Each sample is liver RNA hybridized against a reference RNA consisting of equal parts mouse liver, kidney, and testis RNA. Two of the 4 microarrays per mouse were done with the experimental sa...
ORGANISM(S): Mus musculus 
2006-02-14 | E-MEXP-568 | biostudies-arrayexpress
TranscriptomicsHepatic xenobiotic metabolizing enzyme gene expression through the life stages of the mouse
Using full-genome arrays, the expression of all XMEs was examined during fetal (gestation day (GD) 19), neonatal (postnatal day (PND) 7), prepubescent (PND30), middle age (12 mon), and old age (18 and 24 mon) in the C57Bl6/J mouse liver and compared to young adults. Fetal and neonatal life stages h...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-21716 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis Predicts Clinical Outcome and Sensitivity to Anticancer Drugs of patients with a Pancreatic Adenocarcinoma
A major impediment to the effective treatment of patients with PDAC (Pancreatic Ductal Adenocarcinoma) is the molecular heterogeneity of the disease, which is reflected in an equally diverse pattern of clinical responses to therapy. We developed an efficient strategy in which PDAC samples from 17 co...
ORGANISM(S): Homo sapiens 
2015-04-09 | E-GEOD-55513 | biostudies-arrayexpress
UnknownAssociation of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.
Not available
S-EPMC8168324 | biostudies-literature
UnknownAssociation between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis.

Background

Adequate maternal thyroid function is important for an uncomplicated pregnancy. Although multiple observational studies have evaluated the association between thyroid dysfunction and hypertensive disorders of pregnancy, the methods and definitions of abnormalities in thyroid funct...
S-EPMC10314731 | biostudies-literature
UnknownWhole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification.
Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study (GWAS) of CAC in 22,400 participants from multiple ancestral groups. We confirmed associations with four know...
S-EPMC11138106 | biostudies-literature
UnknownA saturated map of common genetic variants associated with human height.
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 millio...
S-EPMC9605867 | biostudies-literature
UnknownAncient Plasmodium genomes shed light on the history of human malaria.
Malaria-causing protozoa of the genus Plasmodium have exerted one of the strongest selective pressures on the human genome, and resistance alleles provide biomolecular footprints that outline the historical reach of these species1. Nevertheless, debate persists over when and how malaria p...
S-EPMC11222158 | biostudies-literature
UnknownA multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulator...
S-EPMC9388392 | biostudies-literature
UnknownGenetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify f...
S-EPMC6463297 | biostudies-literature
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