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UnknownGenetic variation of staphylococcal LukAB toxin determines receptor tropism.
Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in the coding sequences of core virulence factors. Whether these alterations affect functionality is poorly understood. Here, we studied the highly polymorphic pore-forming toxin LukAB...
S-EPMC8597016 | biostudies-literature
UnknownA living scoping review and online repository of artificial intelligence models in pediatric urology: Results from the AI-PEDURO collaborative.

Introduction

Artificial intelligence (AI) is increasingly being applied across pediatric urology. We provide a living scoping review and online repository developed by the AI in PEDiatric UROlogy (AI-PEDURO) collaborative that summarizes the current and emerging evidence on the AI models dev...
S-EPMC12908176 | biostudies-literature
UnknownMutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation.
Normal vascular development includes the formation and specification of arteries, veins, and intervening capillaries. Vein of Galen malformations (VOGMs) are among the most common and severe neonatal brain arterio-venous malformations, shunting arterial blood into the brain's deep venous system thro...
S-EPMC10292091 | biostudies-literature
UnknownDexamethasone in Hospitalized Patients with Covid-19.

Background

Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death.

Methods

In this controlled, open-label trial comparing a range of poss...
S-EPMC7383595 | biostudies-literature
GenomicsOCAC OncoArray data
Germline genotype data on 56,479 ovarian cancer cases and controls
EGAD00010001192 | EGA
GenomicsThe Ovarian Cancer Association Consortium OncoArray genome-wide association study
A custom Illumina genotyping array, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-rela...
EGAS00001002305 | EGA
GenomicsThe Ovarian Cancer Association Consortium Data Access Committee
Data Access Committee EGAC00001000616
EGAC00001000616 | EGA
UnknownEffect of Hydroxychloroquine in Hospitalized Patients with Covid-19.

Background

Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials.

Methods

In this randomized, controlled, open-label platform trial c...
S-EPMC7556338 | biostudies-literature
UnknownLongitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
Opportunities to interrogate the immune responses in the injured tissue of living patients suffering from acute sterile injuries such as stroke and heart attack are limited. We leveraged a clinical trial of minimally invasive neurosurgery for patients with intracerebral hemorrhage (ICH), a severely ...
S-EPMC8252865 | biostudies-literature
UnknownThe state of US health, 1990-2010: burden of diseases, injuries, and risk factors.

Importance

Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy.

Objectives

To measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to ...
S-EPMC5436627 | biostudies-literature
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