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MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
TranscriptomicsNovel viruses naturally infecting Caenorhabditis nematodes trigger a small RNA response
C. elegans has served as a laboratory model organism due to its ease of manipulation and the availability of both forward and reverse genetics. In recent years, efforts to study host-pathogen interactions in C. elegans have increased. For example, analysis of infections by bacteria such as Pseudomon...
ORGANISM(S): Caenorhabditis elegans 
2011-01-01 | E-GEOD-21736 | biostudies-arrayexpress
ProteomicsHsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes.
Hsp90 is a molecular chaperone involved in the regulation and maturation of kinases and transcription factors. In C. elegans Hsp90 participates in the development of fertility, maintenance of muscle structure and the regulation of stress response and dauer state. To understand the consequences of Hs...
ORGANISM(S): Caenorhabditis elegans 
2018-10-17 | PXD006185 | Pride
Hsp90 Immune system Lc/ms Nematodes 
GenomicsNematodes
Nematodes Metagenome
PRJNA836018 | ENA
TranscriptomicsInitial analysis of copy number variations in cattle selected for resistance or susceptibility to intestinal nematodes
Here we describe the initial analysis of copy number variations in cattle selected for resistance or susceptibility to intestinal nematodes The custom aCGH chips that interrogated the whole genome CNVs were build for 3 pairs of contemporary parasite-susceptible and resistant Angus.
ORGANISM(S): Bos taurus 
2010-12-22 | E-GEOD-21538 | biostudies-arrayexpress
TranscriptomicsGene expression in the duodenum of sheep genetically resistant or susceptible to nematodes
This experiment compared gene expression in the duodenum of [1] weaned genetically resistant sheep and weaned genetically susceptible sheep (84 days old) [2] genetically resistant sheep and genetically susceptible sheep that have been naturally challenged once with nematodes (175 days old) and [3] g...
ORGANISM(S): Ovis aries 
2010-07-01 | E-GEOD-5492 | biostudies-arrayexpress
GenomicsSoil nematodes
Soil nematodes
PRJNA1089647 | ENA
TranscriptomicsThe Drosophila immune response towards entomopathogenic nematodes and their associated bacteria.
Entomopathogenic nematodes (EPNs) of the genera Heterorhabditis are obligate and lethal insect parasites. In recent years they have been used increasingly as biological control agents. These EPNs are symbiotically associated with bacteria of the genera Photorhabdus. The bacterial symbionts are essen...
ORGANISM(S): Drosophila melanogaster 
2014-03-07 | E-MTAB-1542 | biostudies-arrayexpress
TranscriptomicsTranscriptional reprogramming by root knot and migratory nematode infection in rice
In this study a comparison was made between the local transcriptional changes at two time points upon root knot (Meloidogyne graminicola) and migratory nematode (Hirschmanniella oryzae) infection in rice. Using mRNA-Seq we have characterized specific and general responses of the root challenged with...
ORGANISM(S): Oryza sativa Japonica Group 
2013-01-10 | E-GEOD-35843 | biostudies-arrayexpress
GenomicsProfiling DNA methylation in nematodes
Profiling DNA methylation in nematodes
PRJNA412389 | ENA
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