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MetabolomicsMonounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients
Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to ...
2014-06-17 | MTBLS92 | MetaboLights
TranscriptomicsDiscovery cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer. METHODS: We developed a microarray-based gene expression test from pre-treatment tumor biopsies (310 patients) to predict favorable outcom...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-25055 | biostudies-arrayexpress
TranscriptomicsOverall aiEMT in non-cancerous samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32700 | biostudies-arrayexpress
TranscriptomicsOverall aiEMT in surgical samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-33103 | biostudies-arrayexpress
TranscriptomicsIndividual aiEMT in surgical samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32701 | biostudies-arrayexpress
TranscriptomicsTumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies II
Background: Gene expression profiling has been used extensively within breast cancer research. Patient matched transcriptomic studies of tumour samples before and after treatment offer great potential and have been initiated, but tend not to include a control group. Here we examine gene expression c...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-76727 | biostudies-arrayexpress
TranscriptomicsNovel linkages between DCE-MRI and genomic profiling in locally advanced and inflammatory breast cancer
Gene expression signatures have the capacity to identify clinically significant features of breast cancer and can predict which individual patients are likely to be resistant to neoadjuvant therapy, thus providing the opportunity to guide treatment decisions. Data used in publication: Clin Cancer Re...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52322 | biostudies-arrayexpress
GenomicsPDAC Proteomics After Neoadjuvant Therapy
Shotgun Proteomics, Proteomic characterization of the residual PDAC tumor mass after neoadjuvant chemo or combined chemo-radiation therapy
EGAD00010002388 | EGA
TranscriptomicsGene expression profiling of biopsy and resection samples from the DEBIOC phase 1 trial of oxaliplatin and capecitabine +/- AZD8931 in oesophageal cancer
The Dual Erb B Inhibition in Oesophago-gastric Cancer (DEBIOC) trial reported an acceptable safety profile for neoadjuvant Oxaliplatin and Capecitabine (Xelox) +/- AZD8931 in oesophageal adenocarcinoma (OAC) but limited efficacy. We evaluated the impact of neoadjuvant Xelox +/-AZD8931 on biological ...
ORGANISM(S): Homo sapiens 
2024-09-01 | E-MTAB-13741 | biostudies-arrayexpress
TranscriptomicsA specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer
Background: MicroRNAs (miRNAs) are small, non-coding, RNA molecules which regulate numerous cellular processes. Specific miRNA may be abnormally down-regulated or up-regulated in colorectal cancer and have been found associated with prognosis or response to treatments. However, no study has ever ad...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-29298 | biostudies-arrayexpress
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