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MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4933 | MetaboLights
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4932 | MetaboLights
MetabolomicsNeuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

The gut microbiome has been associated with pathological neurophysiological evolvement in extremely premature infants suffering from brain injury. The exact underlying mechanism and its associated metabolic signatures in infants are not fully understood. To decipher metab...

2023-12-30 | MTBLS7560 | MetaboLights
TranscriptomicsMicroarray of neural progenitor cells from neonatal lung injury mice treated with placebo or umbilical-cord mesenchymal stromal cell extracellular vesicles or untreated, as well as age-matched control mice
The purpose of this experiment was to determine the transcriptional differences between neural progenitor cells from neonatal lung injury mice vs. control mice, as well as neonatal lung injury mice treated with umbilical-cord mesenchymal stromal cell extracellular vesicles vs. neonatal lung injury m...
ORGANISM(S): Mus musculus 
2022-05-17 | E-MTAB-11157 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of high-dose recombinant erythropoietin treatment of unilateral brain injury in neonatal mouse hippocampus
Comparison of gene expression in the hippocampus of 10 day old sham-injured and brain-injured BALB-c mice, and examine the effects of high dose Epo on these conditions at 24 hours following injury. Four groups of six mice were treated with epo/no epo, injured/not injured.
ORGANISM(S): Mus musculus 
2015-12-11 | E-GEOD-75865 | biostudies-arrayexpress
TranscriptomicsComprehensive gene expression analysis of cerebral cortices from mature rats after neonatal hypoxic-ischemic brain injury
Neonatal hypoxic-ischemic (HI) encephalopathy can lead to severe brain damage and is a common cause of neurological handicaps in adulthood. To elucidate the molecular events occurring in cerebral cortices of mature rats (8 weeks old) after neonatal HI brain insult, we performed comprehensive gene ex...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-37777 | biostudies-arrayexpress
ProteomicsExtended proteomes of brain organ from individual neonatal rats for understanding hypoxia–ischemia-related brain Injury and drug action.
Next-generation shotgun proteomics of brain organ from individual neonatal rats suffering hypoxia-ischemia related brain injury in order to assess their response to a novel pharmaceutical drug.
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-13 | PXD050059 | Pride
Drug Injury Brain Ischemia Proteomics Encephalopathy Molecular pathways Hypoxia 
TranscriptomicsRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury
We assessed the roles of repopulating microglia in brain repair using mouse models. In this project, we show that removal of microglia from the mouse brain has little impact on the outcome of TBI but inducing the turnover of these cells through either pharmacologic or genetic approaches can yield a ...
ORGANISM(S): Mus musculus 
2020-02-15 | E-MTAB-8765 | biostudies-arrayexpress
ProteomicsDysregulated Hippocampal Fatty Acid Metabolism Following Intermittent Hypoxemia-induced Neonatal Brain Injury is Rescued by Treatment with Acetate – Normoxia vs Intermittent Hypoxia – Sex Difference Analysis
The brain is a lipid-rich organ that experiences rapid growth and development after birth in a period hallmarked by extensive lipid synthesis. We still lack a fundamental understanding of lipid metabolism during this critical time of brain development and how these dynamics occur in infants born ext...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-20 | PXD070491 | Pride
Hippocampus Tmt Orbitrap Mouse Neonatal brain injury Intermittent hypoxia 
MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Brain tissue metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-12-05 | MTBLS4894 | MetaboLights
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