Sort   by:  
 Page size 
MetabolomicsMetabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes
Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling the detection of brain injury. Plasma samples of ...
2021-11-09 | MTBLS1041 | MetaboLights
ProteomicsProteomic analysis of hippocampal proteins in moderate hepatic encephalopathy rat model
Hepatic Encephalopathy is the brain disorder caused by liver damage, characterized by cognitive and motor impairments. Glutamate a predominant excitatory neurotransmitter over activate post-synaptic neuron via NMDAR receptors leads to neuronal derangement. NMDAR as a therapeutic target is not viabl...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-27 | PXD036723 | Pride
Hippocampus Rat Hepatic encephalopathy Lc-ms/ms Label free 
ProteomicsReversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy
Pathogenic heterozygous missense mutations in the DNM1 gene result in a novel form of epileptic encephalopathy. DNM1 encodes for the large GTPase dynamin-1, an enzyme with an obligatory role in the endocytosis of synaptic vesicles (SVs) at mammalian nerve terminals. Pathogenic DNM1 mutations cluster...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-14 | PXD039667 | Pride
Synaptic vesicles Epileptic encephalopathy Dnm1 
UnknownNeonatal encephalopathy: a systematic review of reported treatment outcomes.
Not available
S-EPMC11425948 | biostudies-literature
ProteomicsMislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy
KCNQ2 potassium channel variants are linked to developmental and epileptic encephalopathy (DEE). However, the mechanisms by which pathogenic variants, especially those outside known hotspots, such as the S4–S5 linker, lead to disease remain unknown. Here, we examined the H228R variant, a pathogenic ...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD069563 | Pride
Channel Epilepsy Development Kcnq2 Encephalopathy Immunoprecipitation 
TranscriptomicsGene expression profiling in post mortem brain samples of patients with cirrhosis with and without hepatic encephalopathy
The study aimed at the identification of gene expression changes in brain of cirrhotic patients without or with HE as compared to controls. Tissue was taken from the fusiform gyrus. The dataset comprises 12 brain tissue samples divided into three sample groups each representing a certain liver dise...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-57193 | biostudies-arrayexpress
ProteomicsIdentification of Biomarkers and Therapeutic Targets Related to Sepsis-associated Encephalopathy in Rats by Quantitative Proteomics
Background: Sepsis-associated encephalopathy (SAE) is a common and severe complication of sepsis. While several studies have reported the proteomic alteration in plasma, urine, heart, etc. of sepsis, few research focused on the brain tissue. This study aims at discovering the differentially abundant...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-10 | PXD035112 | Pride
Quantitative proteomics Pi3k/akt signaling Acute phase response Sepsis-associated encephalopathy Gc 
ProteomicsUrinary proteome differences in Hypoxic-Ischemic Encephalopathy newborns
Study utilizes advancements in proteomics technology to analyze urinary protein concentrations, aiming to better understand Hypoxic-Ischemic Encephalopathy brain injury and identify potential therapeutic targets.
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD071111 | Pride
Urine Brain injury Human Newborn 
TranscriptomicsGene expression of rat cerebellum in a new animal model of hepatic encephalopathy (HE)
Identify differentially expressed genes related to the neurodegenerative process in a new animal model of hepatic encephalopathy (HE). The animal model consists on the simulation of several bouts of HE in PCA rats, being the precipitant factors of the episodes ammonia (NH3) and/or lipopolisaccharide...
ORGANISM(S): Rattus norvegicus 
2015-07-29 | E-GEOD-71425 | biostudies-arrayexpress
TranscriptomicsWhite Matter transcriptome in chronic alcoholism
Chronic alcohol consumption can lead to alchohol-related brain damage (ARBD). Despite the well known acute effects of alcohol the mechanism responsible for chronic brain damage is largely unknown. Pathologically the major change is the loss of white matter while neuronal loss is mild and restricted ...
ORGANISM(S): Homo sapiens 
2014-01-04 | E-GEOD-53808 | biostudies-arrayexpress
Sort   by:  
 Page size