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Peroxisome proliferator-activated receptor-gamma (PPARg) regulates the interface between cellular lipid metabolism, redox status and organelle differentiation. Following conditional prostatic epithelial knockout of PPARg in mice we observed focal hyperplasia of the epithelium which developed to mous...
ORGANISM(S): Mus musculus 
To elucidate mechanisms of cancer progression, we generated inducible human neoplasia in 3-dimensionally intact epithelial tissue. Gene expression profiling of both epithelia and stroma at specific time points during tumor progression revealed sequential enrichment of genes mediating discrete biolog...
ORGANISM(S): Mus musculus 
Microsatellite instability analysis of sebaceous neoplasia
In order to understand the molecular mechanism behind Vulvar Intraepithelial Neoplasia (VIN), we have analyzed the gene expression profile of VIN lesions in comparison to controls. Experiment Overall Design: Nine VIN and 10 control samples were collected. RNA of each sample was isolated and analyzed...
ORGANISM(S): Homo sapiens 
Mismatch repair gene sequencing of sebaceous neoplasia
Purpose: Early detection and diagnosis are the keys to improving the survival rate and reducing the fatality rate linked to gastric cancer. The precancerous lesion of gastric cancer is referred to as Gastric high-grade intraepithelial neoplasia (HGIN). Both sensitivity and specificity of current bio...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD036991 | Pride
Comparable plasma lipid changes in patients with high-grade cervical intraepithelial neoplasia and patients with cervical cancer
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-22 | MSV000086351 | GNPS
Most of the carcinogenesis of colorectal cancer (CRC) follows the normal-adenoma-carcinoma (N-A-C) sequence. We aimed to identify the key proteins in the N-A-C sequence and describe the proteomic pattern of tubular adenoma, tubulovillous adenoma and high-grade neoplasia. This study used high-resolut...
ORGANISM(S): Homo Sapiens 
2021-01-30 | PXD023899 |
Sixty-nine (69) tumor samples were collected from patients who underwent thyroidectomy.

The tumors included 22 benign follicular adenomas, 18 follicular carcinomas, 12 samples of microfollicular adenomas, 4 anaplastic carcinomas, 2 papillary carcinomas, and 9 nodular goiters. 23 samples were ...
ORGANISM(S): Homo sapiens 
Twenty-two male volunteers aged 30-70 years with a previous diagnosis of Prostatic Intraepithelial Neoplasia (PIN) were recruited by a consultant urologist at Norfolk and Norwich University Hospital NHS Trust. Ethical approval for the trial was obtained from the Norfolk Research Ethics Committee (re...
ORGANISM(S): Homo sapiens 
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