Neprilysin - OmicsDI

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Unknown (581)
Transcriptomics (67)
Genomics (16)
Proteomics (15)
Metabolomics (1)

Organisms

Homo sapiens (57)
Alphavirus (8)
Anemia (8)
Betaherpesvirinae (8)
Cowpox virus (8)
Coxsackievirus (8)
Cytomegalovirus (8)
Dengue virus (8)
EFO:0001352 (8)
Filoviridae (8)
Hepatitis B virus (8)
Human alphaherpesvirus 1 (8)
Human betaherpesvirus 5 (8)
Human immunodeficiency virus (8)
Human immunodeficiency virus 1 (8)
Human immunodeficiency virus 2 (8)
Mus musculus (7)
Gossypium hirsutum (2)
Glycine max (2)
Populus cathayana (1)
Populus yunnanensis (1)
Phalaenopsis aphrodite subsp. formosana (1)
Ipomoea batatas (1)
Spodoptera frugiperda (1)
Mus musculus domesticus (1)
Oryza sativa Indica Group (1)
Schizosaccharomyces pombe (1)
Nicotiana tabacum (1)
Caenorhabditis elegans (1)
Drosophila melanogaster (1)

Organisms

Homo sapiens (4)
Mus musculus (2)
Drosophila melanogaster (1)

Repository

biostudies-arrayexpress (61)
pride (8)
ENA (8)
EGA (7)
geo (7)
iProX (3)
MassIVE (3)
jPOST (1)
MetaboLights (1)

Tissue

Brain (3)
Urine (2)
Cell culture (1)
Whole body (1)

Disease

Normal (1)
Alzheimer's disease (1)
Prostate cancer (1)
Type 2 diabetes mellitus (1)

Technology Type

Mass Spectrometry (8)
Shotgun proteomics (4)
Mass spectrometry assay (1)
Affinity purification coupled with mass spectrometry proteomics (1)
Data-dependent acquisition (1)
Gel-based experiment (1)
HDMSE (1)
Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (5)
Illumina HiSeq 2500 (3)
Illumina HiSeq 2000 (2)
Illumina Genome Analyzer II (1)
NextSeq 550 (1)
MaXis 4G (1)
Orbitrap Fusion Lumos (1)
Q Exactive (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse-phase (1)
Liquid Chromatography MS - negative - hilic (1)

Publication Date

2015 (9)
2011 (9)
2012 (8)
2026 (7)
2019 (6)
2013 (6)
2025 (5)
2010 (5)
2021 (4)
2014 (4)
2016 (3)
2009 (3)
2008 (3)
2023 (3)
2024 (2)
2018 (2)
2017 (2)
2022 (2)
2004 (1)

Metabolite Name

2-Octyl-4-isothiazolin-3-one (1)
2-(4-chloro-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol (1)
4,13,14-trihydroxy-9-oxo-8,17-dioxatetracyclo[8.7.0.0(2),.0(1)(1),(1)]heptadeca-1(10),2,4,6,11(16),12,14-heptaen-5-yl acetate (1)
[(2R)-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]-2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate (1)
(3r,7r,11r,15r)-3,11-Bis[(5r)-2-amino-4,5-dihydro-1h-imidazol-5-yl]-7,15-dimethyl-1,9-dioxacyclohexadecane-2,10-dione (1)
[4-Hydroxy-3-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-sulooxyphenyl)-2,8-dioxatricyclo[7.3.1.05,13]trideca-1(12),3,5(13),6,9-pentaen-11-ylidene]oxidanium (1)
2-[4-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonatooxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-4-oxobutanoyl]benzoate (1)
(4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid (1)
Unii-WZ5U45K71V (1)
3-(β-D-Galactopyranosyloxy)-2-hydroxypropyl (9Z,12Z)-octadeca-9,12-dienoate (1)
3(S)-Hydroxy-4(R),8-dimethyl-nonanoyl-CoA (1)
3,4,5-trihydroxy-6-({5,6,14-trimethoxy-8,17-dioxatetracyclo[8.7.0.0(2),.0(1)(1),(1)]heptadeca-2,4,6,11(16),12,14-hexaen-4-yl}oxy)oxane-2-carboxylic acid (1)
MAG(16:1) (1)
NCGC00385137-01_C36H58O10_Hexopyranose, 1-O-(3,19,23-trihydroxy-28-oxours-12-en-28-yl)- (1)
5-[(1S,2R)-5,9-dihydroxy-2-(2-hydroxypropan-2-yl)-10-methoxy-11-methyl-6-oxo-1,2-dihydrofuro[2,3-c]acridin-1-yl]-6,10-dihydroxy-11-methoxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one (1)
2,3,4,7,8,9,15,22,23,28-decahydroxy-14-(hydroxymethyl)-12,27,31,34-tetraoxo-13,25,32,35-tetraoxaoctacyclo[14.13.3.3(1),(2).0,(3).0,(1)(1).0(1),(2).0(1),(2).0(2),(3)(3)]pentatriaconta-1,3,5(30),6,8,10,19(24),20,22,28-decaene-20-carboxylic acid (1)
(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,14b-pentamethyl-11-methylidene-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,5-dihydroxy-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxane-2-carboxylic acid (1)
(1R,2S,5R,8S,9R,14S,16R,17S,18R,21R,24R,26S,27R)-5,14,16-trihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone (1)
[6,12,13,14-tetrahydroxy-4-(hydroxymethyl)-9-oxo-11-{6,7,13,14-tetrahydroxy-3,10-dioxo-2,9-dioxatetracyclo[6.6.2.0,(1).0(1)(1),(1)]hexadeca-1(15),4,6,8(16),11,13-hexaen-5-yl}-3,8-dioxatricyclo[8.4.0.0(2),]tetradeca-1(14),10,12-trien-5-yl]oxidanesulfonic acid (1)
(-)-Maackiain-3-O-glucosyl-6''-O-malonate (1)
UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine (1)
[(2S,3S,4S,5S,6R)-6-[(1R)-1,2-dihydroxyethyl]-3,4,5-trihydroxyoxan-2-yl] dihydrogen phosphate (1)
(1R,2R,9R)-1-piperidin-2-yl-3,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane (1)
Magnesium;3-[(21S,22S)-26-ethyl-16-(1-hydroxyethyl)-12,17,21-trimethyl-4-oxo-11-propyl-23,25-diaza-7,24-diazanidahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1,5,8(26),9,11,13(25),14,16,18,20(23)-decaen-22-yl]propanoic acid (1)
[(1S,2R,6S,7R,9R,11R,12S,13S,14S,16R,17S)-16-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-6,12-dihydroxy-2,17-dimethyl-3-oxo-8,15-dioxahexacyclo[9.8.0.02,7.07,9.012,17.014,16]nonadec-4-en-13-yl] acetate (1)
Isopentenyl-Adenosine 13.0 eV (1)
Scorpion (1)
UDP-2-acetamido-2,6-dideoxy-beta-L-talose (1)
(11-Methoxy-16,18-dioxo-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,4,9,11,13(17)-pentaen-14-yl) hydrogen sulate (1)
Arginine Hydrochloride (1)

First Public Date

2019 (3)
2026 (2)
2023 (2)
2025 (1)

Study type

Transcription profiling by array (35)
RNA-seq of coding RNA (8)
RNA-seq of coding RNA from single cells (5)
RNA-seq of non coding RNA (4)
Transcription profiling by SAGE (1)
Animal - High-throughput sequencing (1)
Genotyping by array (1)
Comparative genomic hybridization by array (1)
Other (1)
ScATAC-seq (1)
Single nucleus RNA sequencing (1)
DNA-seq (1)
Methylation profiling by array (1)

Release Date

2025 (86)
2022 (75)
2021 (74)
2023 (66)
2020 (56)
2024 (50)
2019 (39)
2016 (25)
2018 (22)
2015 (20)
2017 (17)
2013 (17)
2012 (16)
2014 (15)
2011 (15)
2026 (14)
2010 (12)
2009 (7)
2008 (6)
2005 (3)
2004 (2)
2007 (2)
2006 (2)
2003 (1)

Lab affiliation

Buck Institute for Research on Aging (1)
Department of Medical Sciences iBiMED University of Aveiro (1)
Department of Pharmaceutical Biosciences Uppsala University (1)
Heiko Meyer, Osnabruck University, Department of Zoology / Developmental Biology, Barbarastr. 11, 49076 Osnabruck, Germany (1)
Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany (1)
Karolinska Institutet, Center for Alzheimer Research, Dept of Neurobiology, Care Sciences and Society, 141 57, Huddinge, Sweden (1)
Lab for Proteolytic Neuroscience, RIKEN Brain Science Institute (1)
Proteomics Laboratory CSIC/UAB, Institut d’Investigacions Biomèdiques de Barcelona (IIBB-CSIC-IDIBAPS), Barcelona, Spain. (1)

Tags

xref:PubMed:30795914 (3)
xref:PubMed:41699135 (1)

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Transcriptomic effects of neprilysin inhibition during endothelin-1–induced hypertrophic stress in human iPSC-derived cardiomyocytes

Human induced pluripotent stem cell–derived cardiomyocytes were used to investigate the cardiomyocyte-intrinsic effects of neprilysin inhibition during hypertrophic stress. Cardiomyocytes were treated with endothelin-1, the neprilysin inhibitor sacubitrilat, a combination of endothelin-1 and sacubit...

ORGANISM(S): Homo sapiens

2026-06-22 | GSE335813 | GEO

Transcriptomic effects of neprilysin inhibition during endothelin-1–induced hypertrophic stress in human iPSC-derived cardiomyocytes

PRJNA1479645 | ENA

Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster.

Not available

S-EPMC8223033 | biostudies-literature

Epigenetic suppression of neprilysin regulates breast cancer invasion.

Not available

S-EPMC4815048 | biostudies-literature

Potential Expanded Indications for Neprilysin Inhibitors.

Not available