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ProteomicsComposition and RNA binding specificity of metazoan RNase MRP
Mechanistic studies have revealed ribonuclease (RNase) MRP, a conserved RNA-based enzyme, is crucial for the maturation of ribosomal RNA in eukaryotes. However, the composition and RNA substrate specificity of this multisubunit ribonucleoprotein complex in higher eukaryotes remain unknown. Here, we ...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD061658 | Pride
Nepro Ribonuclease (rnase) mrp C18orf21 Ip-ms 
GenomicsC18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
C18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
PRJNA1170312 | ENA
OtherC18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
RNase P and RNase MRP are evolutionarily-related ribonucleoprotein complexes that share common protein subunits, but carry out distinct site-specific endonuclease activities. Here, we identify two RNase MRP-specific proteins C18orf21 (RMP24) and Nepro (RMP64). C18orf21 contains a structurally simila...
ORGANISM(S): Homo sapiens 
2025-08-11 | GSE279079 | GEO
ProteomicsC18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
RNase MRP and RNase P are evolutionarily related complexes that facilitate rRNA and tRNA biogenesis, respectively. The two enzymes share nearly all protein subunits and have evolutionarily related catalytic RNAs. Notably, RNase P includes a unique subunit, RPP21, whereas no RNase MRP-specific protei...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD065571 | Pride
Rnase p Rnase mrp Rrna biogenesis 
OtherComposition and RNA binding specificity of metazoan RNase MRP
Ribonuclease (RNase) MRP is a conserved RNA-based enzyme that is essential for maturation of ribosomal RNA (rRNA) in eukaryotes. However, the composition and RNA substrate specificity of this multisubunit ribonucleoprotein complex in higher eukaryotes remain a mystery. Here, we identify NEPRO and C1...
ORGANISM(S): Mus musculus 
2025-08-05 | GSE290995 | GEO
UnknownComposition and RNA binding specificity of metazoan RNase MRP.
Not available
S-EPMC11870539 | biostudies-literature
UnknownThiazide diuretic-caused hyponatremia in the elderly hypertensive: will a bottle of Nepro a day keep hyponatremia and the doctor away? Study protocol for a proof-of-concept feasibility trial.
Not available
S-EPMC5889541 | biostudies-literature
UnknownRNase MRP subunit composition and role in 40S ribosome biogenesis.
Not available
S-EPMC12819141 | biostudies-literature
UnknownComposition and RNA binding specificity of metazoan RNase MRP.
Not available
S-EPMC12390755 | biostudies-literature
GenomicsComposition and RNA binding specificity of metazoan RNase MRP
Composition and RNA binding specificity of metazoan RNase MRP
PRJNA1231220 | ENA
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