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TranscriptomicsDNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes
The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5’-3’ direction ...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-65985 | biostudies-arrayexpress
TranscriptomicsMiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2.2.15 cells.
Deficient DNA repair capacity is associated with genetic lesions accumulation and susceptibility to carcinogenesis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate various cellular pathways including DNA repair. Here we hypothesized that the existence of HBV products may interfere with ce...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-27561 | biostudies-arrayexpress
ProteomicsAnd-1 is required for NER repair and promotes skin carcinogenesis
Our project was focused on And-1 regulates NER repair and skin carcinogenesis
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD052800 | Pride
And-1 Ner repair Skin carcinogenesis 
GenomicsElf1 promotes TC-NER in yeast by using its C-terminal domain to bind TFIIH
Elf1 promotes TC-NER in yeast by using its C-terminal domain to bind TFIIH
PRJNA1018995 | ENA
GenomicsThe yeast GG-NER complex evicts histone H2A.Z-containing barrier nucleosomes from CID boundaries during DNA repair
Background: Repair of DNA damage requires chromatin remodeling to permit removal of the lesions. How nucleosomes are remodelled to initiate repair of DNA damage remains largely unknown. Here, we describe how chromatin is altered during repair of UV-induced DNA damage at the level of the linear organ...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-06 | E-MTAB-6569 | biostudies-arrayexpress
TranscriptomicsExpression changes in Caenorhabditis elegans xpa-1 mutant
Background: The ability of an organism to repair DNA damage is implicated in carcinogenesis and aging. Interestingly expression profiling of Nucleotide Excision Repair (NER) deficient segmental progeroid mice revealed gene expression changes resembling these observed in aged wild type animals. Our p...
ORGANISM(S): Caenorhabditis elegans 
2013-05-03 | E-GEOD-39252 | biostudies-arrayexpress
OtherElf1 promotes TC-NER in yeast by using its C-terminal domain to bind TFIIH
Transcription coupled-nucleotide excision repair (TC-NER) repairs DNA lesions that stall RNA polymerase II (Pol II) transcription. Here, we show that the C-terminal domain (CTD) of elongation factor-1 (Elf1) plays a critical role in TC-NER in yeast. Analysis of genome-wide repair of UV-induced cyclo...
ORGANISM(S): Saccharomyces cerevisiae 
2024-05-31 | GSE243603 | GEO
GenomicsThe yeast GG-NER complex evicts histone H2A.Z-containing barrier nucleosomes from CID boundaries during DNA repair
The yeast GG-NER complex evicts histone H2A.Z-containing barrier nucleosomes from CID boundaries during DNA repair
PRJEB25412 | ENA
TranscriptomicsTranscription profiling of liver from Csbm/m/Xpa-/- knockout mice to investigate the effect of nucleotide excision repair pathway inactivation
Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria caused by a defect in the transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csbm/m/Xpa-/- mutants causes a phenotype that reliably mimics th...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-835 | biostudies-arrayexpress
UnknownNegative expansion resistance (NER) phenomenon predicts hemodynamically non-significant coronary lesions.
Not available
S-EPMC12708762 | biostudies-literature
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