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TranscriptomicsClassification of Myeloma Using Global MicroRNA Profiling
Myeloma is a heterogeneous disease. In this work we used global microRNA profiling to classify clinical samples from UK MRC Myeloma IX, and developed a microRNA-based M-bM-^@M-^\outcome classifierM-bM-^@M-^] for risk stratification. Global microRNA expression profiling was carried out in 163 newly d...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-41276 | biostudies-arrayexpress
UnknownContribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function.
Not available
S-EPMC3510752 | biostudies-literature
ProteomicsCharacterization of novel a-Mangostin and Paeonol derivatives with cancer-selective cytotoxicity
a-Mangostin and Paeonol have shown anti-cancer and anti-inflammatory properties, however these two natural compounds have no clinical value because of their low solubility and low membrane permeability. In this study, we screened chemically synthesized derivatives from these two natural compounds as...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024999 | Pride
Colorectal cancer  anti-cancer drugs  cancer-selective compounds  natural compound derivatives  colon cancer organoids  paeonol  a-mangostin 
GenomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35854 | biostudies-arrayexpress
TranscriptomicsSmall nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multiple myeloma.
Small nucleolar RNAs (snoRNAs) and small Cajal body-specific RNAs (scaRNAs) are non-coding RNAs involved in the maturation of other RNA molecules and generally located in the introns of host genes. It is now emerging that altered sno/scaRNAs expression may play a pathological role in cancer. This st...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-39683 | biostudies-arrayexpress
Unknown30 Years of simultaneous crop & land cover land use maps for Middle Rio Grande from 1994 to 2024.
Not available
S-EPMC12370968 | biostudies-literature
GenomicsIdentification of Myc and Max genomic targets in mouse embryonic stem cells.
Myc is a master transcription factor that has been demonstrated to be required for embryonic stem cell (ESC) pluripotency, self-renewal, and inhibition of differentiation. Although recent works identified several Myc-targets in ESC the list of Myc binding sites is largely incomplete due to the low s...
ORGANISM(S): Mus musculus 
2014-03-05 | E-GEOD-48175 | biostudies-arrayexpress
GenomicsTranscriptional regulation of Tet1 during development
5-hydroxymethylcytosine (5hmC) is a recently discovered epigenetic modification that is lost in human cancers. Formation of 5hmC is catalysed by the Ten eleven translocation (TET) proteins that mediate the sequential oxidation of 5-methylcytosine (5mC) to 5hmC, leading to eventual DNA demethylation....
ORGANISM(S): Mus musculus 
2015-08-04 | E-GEOD-57250 | biostudies-arrayexpress
TranscriptomicsA SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma
A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide dosage effect on gene and microRNA expression This SuperSeries is composed of the following subset Series: GSE13591: Integrated genomics approach to detect alle...
ORGANISM(S): Homo sapiens 
2009-05-16 | E-GEOD-16122 | biostudies-arrayexpress
GenomicsSingle base resolution analysis of 5-formyl and 5-carboxyl cytosine reveals the actual promoter DNA methylation dynamics in embryonic stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-55660 | biostudies-arrayexpress
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