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ProteomicsBiomarker Discovery in FFPE tissues by SRM
The identification of clinically relevant biomarkers represents an important challenge in oncology. This can be addressed with biomarker discovery studies in formalin-fixed paraffin-embedded (FFPE) tissues. However, reliably measuring large sets of proteins in FFPE tissues remains challenging. Here ...
ORGANISM(S): Homo Sapiens 
2022-09-25 | PXD025135 | panorama
TranscriptomicsGene Expression data from Mouse Balb/c Bone marrow derived macrophages infected by the promastigote form of Leishmania major parasite (P) or Killed parasite (Kp) during a time course of infection [Balb/c]
We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages (BMDM) at different times after infection with promastigotes of the protozoan parasite Leishmania major. GeneChip Mouse Gene 1.0 ST arrays were used to analyse global changes in gene transcripts to generate a pool of...
ORGANISM(S): Mus musculus 
2012-11-19 | E-GEOD-31995 | biostudies-arrayexpress
TranscriptomicsAnalysis of cardiac gene expression in response to isoproterenol-induced heart failure (part 1)
Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to ind...
ORGANISM(S): Mus musculus 
2010-05-31 | E-GEOD-16243 | biostudies-arrayexpress
TranscriptomicsAnalysis of cardiac gene expression in response to isoproterenol-induced heart failure (part 2)
Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to ind...
ORGANISM(S): Mus musculus 
2010-05-31 | E-GEOD-16246 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neuroblastoma tumors with and without MYCN amplification
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-2 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cells with and without MYCN oncogene induction and doxorubicin treatment
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-3 | biostudies-arrayexpress
TranscriptomicsExpression data from pulmonary metastases of clear-cell renal cell carcinoma
The understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis, like varying dormancy periods of Mets originating from the same primary tumor entity or the differing number of Mets in patients with the same primary tumor, are largely unkno...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-14378 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human primary breast cancer tissue before treatment with gemcitabine, epirubicine and docetaxel
Gene expression profiles of human breast cancer tissues from 100 different patients treated with primary systemic chemotherapy (Gemcitabine, Epirubicin and Docetaxel) Keywords: expression profiling Human breast cancer tissues from 100 patients have been used to perform expression profiling analysis...
ORGANISM(S): Homo sapiens 
2006-01-21 | E-GEOD-4056 | biostudies-arrayexpress
TranscriptomicsHuman medulloblastoma samples
Purpose Integrated genomics approaches have identified at least four distinct biological variants in medulloblastoma: WNT, SHH, group C, and group D. Non-WNT/Non-SHH tumors are associated with metastatic dissemination and an unfavorable prognosis. Additional markers may enhance outcome prediction in...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-28245 | biostudies-arrayexpress
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