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TranscriptomicsJnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-40041 | biostudies-arrayexpress
UnknownBRCA1/2 Mutations and Bevacizumab in the Neoadjuvant Treatment of Breast Cancer: Response and Prognosis Results in Patients With Triple-Negative Breast Cancer From the GeparQuinto Study.
Not available
S-EPMC6067803 | biostudies-literature
TranscriptomicsReal-time quantitative PCR analysis of hormone-receptor-negative primary breast tumors
Total RNA was extracted from FFPE samples of 139 chemotherapy-naïve hormone-receptor-negative breast cancers pooled from three sample sources and assayed for the expression of 21 genes within two previously reported microarray-derived prognostic signatures in 6 RT-PCR multiplexes. RT-PCR gene expre...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51630 | biostudies-arrayexpress
UnknownMyosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.
Not available
S-EPMC5393228 | biostudies-literature
Unknown18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.
Not available
S-EPMC5849499 | biostudies-literature
Proteomics- Identification of Gαi2-interacting proteins via affinity pull-down and quantitative mass-spectrometry analysis.
In studying patients with activating GNAI2 mutations, we observed T cell hyperresponsiveness that was independent of cAMP suppression. Therefore, we hypothesized that Gαi2 utilizes alternative signal transduction pathways which might be delineated by identifying its interacting proteins in T cells. ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-09-20 | PXD048980 | Pride
Gpcrs G-protein coupled receptors Gnai2 - gαi2 G-protein 
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - whole genome sequencing
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. Demuxlet was used to ...
ORGANISM(S): Homo sapiens 
2018-10-17 | E-MTAB-7304 | biostudies-arrayexpress
UnknownGenetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies.
Not available
S-EPMC10689924 | biostudies-literature
UnknownAdjuvant Olaparib for Patients with <i>BRCA1</i>- or <i>BRCA2</i>-Mutated Breast Cancer.
Not available
S-EPMC9126186 | biostudies-literature
UnknownGermline mutations in a G protein identify signaling cross-talk in T cells.
Not available
S-EPMC11811912 | biostudies-literature
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