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ProteomicsAmyloid Beta A4 Precursor Protein-binding Family B Member 1 (FE65) Interactomics Revealed Synaptic Vesicle Glycoprotein 2A (SV2A) and Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 (SERCA2) as New Binding Proteins in the Human Brain
FE65 is a cytosolic adapter protein and an important binding partner of the amyloid precursor protein (APP). Dependent on Thr668 phosphorylation in APP, which influences amyloidogenic APP processing, FE65 undergoes nuclear translocation, thereby transmitting a signal from the cell membrane to the nu...
ORGANISM(S): Homo sapiens (Human) 
2016-05-18 | PXD000437 | Pride
Brain Human Fe65 
ProteomicsDeletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer
Activation of the mechanistic target of rapamycin (mTOR) pathway is frequently found in cancer, but mTOR inhibitors have thus far failed to demonstrate significant antiproliferative efficacy in the majority of cancer types. Besides cancer cell-intrinsic resistance mechanisms, it is conceivable that ...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-05 | PXD019998 | Pride
Liver metastasis Mtor Nf-ĸb signaling 
TranscriptomicsRNAseq of mutant TP53 HCT116 cell line clones generated via CRISPR editing
To compare the impact of several TP53 mutant variants in an isogenic setting, different TP53 mutations were introduced in HCT116 colorectal carcinoma cells. This parental cell line is wild-type for TP53 and shows a prototypical p53 response. To ensure unambigous genotype-phenotype correlations, the ...
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-12734 | biostudies-arrayexpress
TranscriptomicsAmplicon-Screening of exonic RNA in exon-wide mutant cell libraries of mutant TP53 (Exons 5, 6, 7, 8) in HCT116 cells generated via CRISPR editing
To compare the impact of TP53 mutant variants in exon-wide mutant cell libraries, comprehensive mutome libraries of TP53 affecting the Exons 5, 6, 7 and 8 were generated systematically by CRISP/Cas9 editing in HCT116 colorectal carcinoma cells.
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-12861 | biostudies-arrayexpress
GenomicsAmplicon-Screening of exonic DNA regions in exon-wide mutant cell libraries of mutant TP53 (Exons 5, 6, 7, 8) in HCT116 cells generated via CRISPR editing
To compare the impact of TP53 mutant variants in exon-wide mutant cell libraries, comprehensive mutome libraries of TP53 affecting the Exons 5, 6, 7 and 8 were generated systematically by CRISP/Cas9 editing in HCT116 colorectal carcinoma cells.
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-12857 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq of haploidized HCT116 colorectal carcinoma cells expressing specific p53 mutations treated with either DMSO or Nutlin
Colorectal carcinoma cell line HCT116 cells were used as a model system to investigate the heterogeneity of different TP53 mutations. To this end, cells were haploidized by deleting an intronic splice site in one of the two wild-type TP53 alleles while the other copy was altered to different loss-of...
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-13904 | biostudies-arrayexpress
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