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MetabolomicsElevated lysophosphatidylcholines during SSRI-induced neural differentiation correlate with early neurodevelopmental symptoms

Background: Selective serotonin reuptake inhibitors (SSRIs) are often prescribed during pregnancy. Yet, epidemiological studies link in-utero SSRI exposure with neurodevelopmental disorders, such as autism and ADHD. The potential molecular mechanisms by which SSRIs impact early n...

2026-04-02 | MTBLS12645 | MetaboLights
MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Feces metabolomics)

Maternal folic acid intake is crucial for the development of the offspring's nervous system, and folic acid metabolism disorders during pregnancy lead to neural tube defects (NTDs) in the fetus. Folic acid and vitamins biosynthesis is a major biochemical feature of gut microbiota. The complex and...

2022-12-05 | MTBLS4893 | MetaboLights
MetabolomicsDynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages

Single-cell metabolomics reveals cell heterogeneity and elucidates intracellular molecular mechanisms. However, general concentration measurement of metabolites can only provide a static delineation of metabolomics, lacking the metabolic activity information of biological pathways. Herein, we dev...

2025-04-14 | MTBLS11091 | MetaboLights
MetabolomicsTime-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury

Perioperative neurocognitive disorders (PND) pose a significant challenge for aging surgical patients, with sevoflurane anesthesia being an identified risk factor. Time-restricted feeding (TRF), a dietary regimen, shows promise in mitigating age-related cognitive decline, but its efficacy and mec...

2026-02-17 | MTBLS13891 | MetaboLights
TranscriptomicsIsolation and transcriptional profiling of embryonic human neural crest cells
To identify new candidate genes for neurocristopathies, a Long-SAGE library has been made from human neural crest cells (hNCC) derived from a normal embryo at Carnegie stage 13. Data analysis indicates the expression of a number of genes in multiple GO functional classes that were anticipated based...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-GEOD-8368 | biostudies-arrayexpress
TranscriptomicsPax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers [Xenopus_laevis]
Neural crest development is orchestrated by a complex and still poorly understood gene regulatory network. Premigratory neural crest is induced at the lateral border of the neural plate by the combined action of signaling molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1. Among th...
ORGANISM(S): Xenopus laevis 
2013-12-28 | E-GEOD-53678 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq and microRNA-Seq whole-transcriptome analysis of rhesus monkey ESC neural differentiation revealed the potential rosette neural stem cell regulators
Rosette neural stem cells (R-NSCs) represent early stage of neural development and possess full neural differentiation and regionalization capacities. R-NSCs are considered as stem cells of neural lineage and have important implications in study of neurogenesis and cell replacement therapy. However,...
ORGANISM(S): Macaca mulatta 
2014-07-03 | E-GEOD-53260 | biostudies-arrayexpress
MetabolomicsLipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging (Part 3)
Not available
ORGANISM(S): Mus musculus 
ST002259 | MetabolomicsWorkbench
GenomicsChIP-seq on p300, NFI and H3K27ac in mouse neural stem cells
Definition of genome wide transcriptional enhancers by overlap of p300 and H3K27ac and the role of NFI factors in the regulation of mouse neural stem cells
ORGANISM(S): Mus musculus 
2013-08-12 | E-MTAB-1423 | biostudies-arrayexpress
TranscriptomicsGeminin-regulated genes during neural fate acquisition of mouse embryonic stem cells
Formation of the complex vertebrate nervous system begins when pluripotent cells of the early embryo are directed to acquire a neural fate. Although cell intrinsic controls play an important role in this process, the molecular nature of this regulation is not well defined. Here we assessed the rol...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25737 | biostudies-arrayexpress
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